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“Noisy” gene expression may help improve stem cell therapies
Researchers have identified a process that amplifies changes in gene expression, which could be harnessed to accelerate stem cell differentiation.
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Induced Pluripotent Stem Cells (iPSCs)
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Scientists publish guide for creating mouse-human chimeric embryos
Researchers have published a step-by-step protocol on how to produce millions of mature human cells in a chimeric mouse embryo.
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Transcriptional reprogramming rescues vascular fate of misidentified pluripotent cell‑derived epithelial cells
A team of scientists has found that a type of cell derived from human stem cells and widely used for brain research and drug development may have been leading researchers astray for years. Here, Dr Raphaël Lis from Weill Cornell Medicine explains how forcing the activity of three known endothelial cell transcription…
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Drug development in stem cell-derived liver organoid models
To ensure that new drugs are effective and have as little toxicity as possible, they first need to be tested in model systems before entering clinical trials. In this Q&A, Dr Takanori Takebe outlines his research into liver organoids derived from stem cells that can be used to test new…
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Drug Target Review Stem Cells ebook 2021
Included in this ebook are articles on stem cell-derived liver organoids and pluripotent cell-derived endothelial cells.
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Off-the-shelf T-cell therapy from gene edited stem cells
Dr Jo Brewer outlines research into allogeneic products by gene editing stem cells, which has the potential to build a broad family of multiple immune cell types, including T-cell therapies.
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Tiny implant cures diabetes in mice without triggering immune response
Scientists have developed an implant that releases insulin-secreting cells which has shown success at treating diabetes in mice.
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Stem cell-based vaccine protects mice against pancreatic cancer
Researchers have developed a vaccine using stem cells that protected mice injected with pancreatic cancer cells from developing tumours.
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Small-molecule cocktail could improve use of stem cells in treatments
Researchers have shown that Chroman 1, Emricasan and trans-ISRIB, in combination with polyamines, are effective at protecting induced pluripotent stem cells from stress.
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Stem cell therapy repairs damage from dementia in mouse brains
Researchers have developed a stem cell therapy that could treat the damage caused by dementia by launching a repair response.
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Scientists generate human-monkey chimeric embryos
An international collaboration has led to the development of monkey embryos able to grow with injected human stem cells.
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Technique developed for delivery of iPSCs to treat type I diabetes mellitus
A team has developed a lotus-root-shaped construct to deliver iPSC-derived pancreatic beta-cells to patients with type I diabetes mellitus.
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Researchers study iPSCs to uncover genetic causes of disease
Sequencing and transcriptome data on iPSCs has been used to identify correlations between genetic variants and expression patterns.
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CRISPR used to model acute myeloid leukaemia progression
CRISPR-Cas9 and stem cell technologies have been used to create a cellular model of acute myeloid leukaemia, revealing therapeutic targets.
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Novel enterocyte-like cells developed by researchers from stem cells
A team has developed enterocyte-like cells from hiPSCs, which can be used to study the absorption of novel oral drugs.
