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Functioning lung cell assay for modelling COVID-19 infections developed
A UK company has announced that their lung epithelium model can successfully be used to test potential treatments for COVID-19.
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Induced Pluripotent Stem Cells (iPSCs)
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iPSC-derived natural killer cells show promise against leukaemia in mice
By deleting the CISH gene from natural killer cells made from iPSCs, researchers say they have effectively treated leukaemia in vivo and in vitro.
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Application of organoid technology for retinal disease modelling and drug discovery
The loss of retinal light-sensing photoreceptor cells is a leading cause of blindness and the number of individuals affected by retinal degenerative diseases is increasing with an ageing population. Currently, there are no treatments for these diseases and progress in finding new treatments is slow. This article explores the potential…
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Using big data approaches to develop cell therapies
An area where stem cell biology and medicine are combining effectively is the establishment of new cell therapies. However, current therapies are limited to a narrow set of cell types that can be isolated or created and expanded in vitro. Dr Owen Rackham discusses how utilising computational approaches will further…
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Induced pluripotent stem cells and CRISPR reversed diabetes in mice
Induced pluripotent stem cells made to produce insulin and CRISPR, used to correct a genetic defect, cured Wolfram syndrome in mice.
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The growing possibilities for stem cells in pharma
Drug Target Review explores the latest applications of stem cells in modelling disease, drug production and the most recent steps in regenerative medicine provided by research.
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Researchers use iPSCs to treat neuropathic pain in mice
Induced pluripotent stem cells (iPSCs) have been administered to mice with neuropathic pain to provide lasting relief with no side effects.
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MLL gene key to producing hematopoietic stem cells, says research
Researchers investigating childhood leukaemia have discovered that increasing MLL gene expression in iPSCs drives hematopoietic stem cell production, so could be the target of new therapies.
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Accurate model of organ scarring created using stem cells in a lab
Researchers have developed a 'scar in a dish' model derived from human stem cells which mimics the progressive scarring that occurs in human organs and has lead to a drug candidate being identified to stop the progression of fibrosis.
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Machine learning programme used to predict stem cell growth
Researchers have used machine learning to predict the conditions needed for stem cells to develop a certain way, which could be used to grow 3D organ models.
webinar
Phenotypic screening using iPSC-based human disease biology
18 February 2019 | By Tecan and Ncardia
Ncardia, will discuss the application of human iPSC-derived cell-based assays and high throughput screening for drug discovery and development.
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Scientists report using pluripotent stem cells to grow human oesophagal organoids
Scientists have been able to grow human oesophagal tissue entirely from pluripotent stem cells (PSCs), which can form any tissue type in the body...
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3D liver tissue made from stem cells show promising support of liver function
Stem cells transformed into 3D human liver tissue by scientists show promising support of liver function when implanted into mice with a liver disease...
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CRISPRa used to reprogramme skin cells into pluripotent stem cells
Researchers have now for the first time succeeded in converting skin cells into pluripotent stem cells by activating the cell's own genes...
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CRISPR technology may improve accuracy of predicting heart disease risk
Scientists may now be able to predict whether carrying a specific genetic variant increases a person's risk for disease using gene editing and stem cell technologies...