Label-Free

MRI technique differentiates benign breast lesions from malignancies

20 February 2018 | By Dr Zara Kassam (Drug Target Review)

An MRI technique that requires no contrast agent, combined with sophisticated data analysis, could reduce the number of unnecessary breast biopsies...

Gene manipulation holds the key to personalised medicine

5 February 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers propose a novel approach to manipulate genes that may hold the key to the future of personalised medicine...

Streamlining drug discovery assays for cancer and cardiovascular disease

1 February 2018 | By PerkinElmer

This webinar discussed a screening assay that recapitulates the activation of ER stress sensor IRE1 and an assay to quantify cell migration phenotypes, as applied to cardiovascular target validation and drug discovery.

DRD2 crystal structure provides antipsychotic drug development tool

26 January 2018 | By Dr Zara Kassam (Drug Target Review)

Crystal structure of the dopamine 2 receptor bound to an antipsychotic drug provides a much-needed discovery in the quest to create effective drugs with fewer side effects...

Cryo-EM reveals critical OST complex and potential drug target

24 January 2018 | By Dr Zara Kassam (Drug Target Review)

Scientists have revealed the atomic-level structure of a molecular complex responsible for modifying proteins, paving the way for the development of new medications...

Blood-vessel-on-a-chip provides insight into new anti-inflammatory drug candidate

17 January 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers have discovered that synthetic APC-mimicking molecules provide anti-inflammatory and anti-thrombotic protection to endothelial cells without interfering with blood clotting...

A pragmatic approach to hit validation following biochemical high-throughput screening

12 December 2017 | By Dr Agnes Martin, Dr Laurent Rigoreau, Dr Sheila McLoughlin

Progressing actives from a high-throughput screen (HTS) of a target protein into suitable starting points for lead identification is fraught with pitfalls. The volume and quality of the HTS output is a function of the quality of the screening library, as well as specific properties of both the target and…

Diagnosing cancer: new process for identifying biomarkers established

7 April 2017 | By Niamh Marriott (Drug Target Review)

Scientists have established a process for identifying biomarkers for the diagnosis of different types of cancer.

Molecular Devices

Inhibition of RNA-containing viruses by artificial RNases

16 June 2016 | By Dmitry Klinov (Federal Medical and Biological Agency of the Russian Federation), Elena Isaeva (D. I. Ivanovsky Institute of Virology), Ludmila Koroleva (Siberian branch of the Russian Academy of Sciences), Olga Morozova (D. I. Ivanovsky Institute of Virology and Federal Medical and Biological Agency of the Russian Federation), Vladimir Silnikov (Siberian branch of the Russian Academy of Sciences)

The toxicity and antiviral properties of 24 low-molecular-weight artificial RNases (artRNases) including peptides, peptidomimetics, N-alkyl-substituted 1,4-diazabicyclo[2.2.2]octane (DABCO) and a silver (I) complex with cystine were analysed for viruses containing single-stranded and double-stranded genomic RNA (the tick-borne encephalitis virus; TBEV and the influenza virus, respectively) in vitro and in vivo by…

Label-free technologies for monitoring drug interactions

9 April 2015 | By Jean-Francois Masson (Universite de Montreal and Centre for Self-Assembled Chemical Structures), Kristy McKeating (Universite de Montreal)

In his fascinating overview of label-free analysis, Dr. Masson introduces the four main label-free methods: physical, electrochemical, mass-based and optical techniques, before providing the reader with in-depth insight into the most common label-free technique within the pharmaceutical industry: surface plasmon resonance (SPR)...