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15 January 2018 | By BMG Labtech GmbH
Optimising the receptor binding kinetics of new drugs can have significant benefits, ranging from improved duration of action to enhanced efficacy through the insurmountable antagonism of dynamic physiological systems.Despite this, the kinetics of new receptor ligands are rarely measured early in the drug discovery process, largely because current assays are…
Scientists at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) have succeeded in revealing a key mechanism of membrane deformation.
The growth-arrest specific 6 (GAS6) protein has emerged in recent years as an attractive target for drug development primarily because it is the sole ligand for the AXL receptor tyrosine kinase, which plays critical roles in cancer, fibrosis, and viral infection.
A team of scientists from Austria, Australia, Denmark, England and the Czech Republic, led by Christian Gruber from the MedUni Vienna's Institute of Pharmacology, managed to isolate a neuropeptide from ants that is very similar to the human love hormone oxytocin, and the closely related hormone vasopressin.
Ligands are useful tools for studying how proteins work in cells and could lead to the development of new drugs.
21 December 2016 | By DiscoverX Corporations
Optimized Assays for a Multitude of GPCR Applications...
15 June 2016 | By Victoria White, Digital Content Producer
Scientists from The Scripps Research Institute have developed a powerful new method for finding drug candidates that bind to specific proteins...
15 October 2015 | By Charles River
Ligand-gated ion channels including, GABAA, NMDA, and nicotinic acetylcholine receptors, are important therapeutic targets in neurological disorders...
