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Label-free technique used to visualise lipid content in mouse livers
Researchers have successfully used label-free near-infrared hyperspectral imaging for mouse livers, which could aid in the diagnosis of NAFLD.
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Lipidomics
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Synthesising very long-chain fatty acids to treat retinal conditions
A class of lipids – or fatty acids – found in the retina of the eye play an important role in maintaining vision. Victoria Rees, Deputy Editor of Drug Target Review, spoke with Dr Paul Bernstein from the Moran Eye Center at the University of Utah, US, to discover how…
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Application note: Metagenomic analysis of the microbiome with MagMAX
The isolation of microbial DNA is a key prerequisite for determining the microbiome profile of each body habitat.
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Drug Target Review – Issue 1 2021
In this issue, find articles discussing how high-throughput experimentation can enhance automated molecular discovery, why bNAbs present a promising COVID-19 treatment and how a novel rhinovirus vaccine was developed. Also included are features on immuno-oncology, cell line development and assays.
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Catalogue: Nuclease-Free tubes, tips & buffers
Working with RNA requires rigorous nuclease contamination controls in place. Stock up on Nuclease-Free tubes tips and buffers #Back2Lab
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Brochure: Dynabeads manual and automated SARS-CoV-2 enrichment
Achieve intact SARS-CoV-2 virus enrichment products. You only need a centrifuge, and the intact virus is enriched in less than 3 hours with very little hands-on time.
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Catalogue: KingFisher APEX is the pinnacle of automated extraction
KingFisher APEX is our newest instrument for automation workflows for high throughput DNA and RNA extraction. With precision handling and touch screen interface.
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Catalogue: Ribosomal RNA from bacteria with RiboMinus
RiboMinus Bacteria 2.0 Transcriptome Isolation Kits perform efficient transcriptome enrichment from total bacterial RNA. Improve your RNA extraction from bacteria today.
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DNA reference guide: Sample preparation solutions
See our guide on DNA purification methods. From organic extraction through automated high-throughput runs, these research solutions make sample preparation easy.
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Hymecromone can suppress neuroinflammation in astrocytes, study shows
Researchers have found that the spasmolytic drug hymecromone can suppress astrocyte inflammatory responses, meaning it could be used to combat Alzheimer's disease.
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Blocking Treg pathway sensitises mice to immunotherapy
Researchers have shown that inhibiting Treg activation in tumours can provide effective immune responses without autoimmune toxicity.
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PI3K signalling pathway revealed as potential drug target for obesity
Researchers have found that the PI3K signalling pathway could be targeted to prevent liptoxicity and combat obesity.
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Could a sphingosine nasal spray prevent COVID-19?
According to a study, the lipid sphingosine can inhibit SARS-CoV-2 infection and could potentially be delivered in a nasal spray to prevent COVID-19 infections.
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How do general anaesthetics cause loss of consciousness?
Inhaled general anaesthetics have been used for over 100 years and continue to be used daily for surgeries around the world. But how do they induce changes to consciousness? This article explores the research that suggests the anaesthetics chloroform and isoflurane disrupt the organisation of lipid rafts within cellular membranes…
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Lipid mediators suggested as potential COVID-19 inflammation treatment
A new article has outlined the body's inflammatory response to COVID-19 infection, saying that lipid mediators derived from omega-3 fatty acids could prevent life-threatening inflammation.