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For the past thirty years, native mass spectrometry has grown in both scope and reach in labs across the globe to encompass larger and more challenging molecular complexes. However, up until now, the throughput of these techniques has been slow and manual. Christopher Nortcliffe discusses ways that native analysis is…
This in-depth focus discusses screening and the uses of phenotypic profiling in drug discovery. Also examined is the role that CRISPR/Cas9 gene editing and native mass spectrometry play.
In this issue: novel approaches to produce radiolabelled antibodies, the use of CRISPR/Cas9 to accelerate the development of targeted therapies and utilisation of stem cells to study the effects of cannabis on neuronal development.
Researchers succeed in using machine learning to make the mass analysis of proteins faster and almost error-free.
New method for computational mass spectrometry will speed up the discovery of natural products that could be used in medicines...
Over the last five years drug discovery has undergone a rapid evolution from a closed and proprietary endeavour to an open and collaborative process. Large and small pharma now openly collaborate with each other and the wider academic world to leverage their collective depth of knowledge to increase the chances…
Development and production of biopharmaceuticals is complex. Even minor impurities, or changes in attributes such as glycosylation or charge heterogeneity, can have a profound impact on the safety and efficacy of the final product. Traditionally, multiple analytical techniques have been required to assess the full range of biopharmaceutical product attributes.…
An international team of scientists has developed a candidate identification technique in the form of an algorithm that reduces the chances of rediscovering known compounds.
New approach could prolong survival and trigger an immune...
Since the development of the so-called soft ionisation techniques: electrospray ionisation and matrix-assisted laser desorption and ionisation in the 1980s and early 1990s and the development of high-resolution mass spectrometers, mass spectrometry (MS) has come to the fore in studying complex biological systems...
In a series of experiments, researchers have used an experimental compound to successfully reverse hair loss, hair whitening and skin inflammation...
Breath tests analysing organic compounds in exhaled breath could be used as a new diagnostic tool for pancreatic cancer...
Reversing modifications in diseased heart muscle cell struts called microtubules (MT) can lessen the stiffness and improve the beating strength of these cells isolated from transplant patients with heart failure.
Although readers of Drug Target Review may be more focused upstream of clinical trials in the drug discovery pipeline, the efficacy of clinical trials should also be of interest. Millions of pounds invested in drug discovery in the laboratory could easily go to waste if the clinical trials stage is…
