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Drug Target Review – Issue #2 2017
Included in this issue: Technology convergence improves testing; Screening; Stem Cells; Targets; Mass Spectrometry; and Therapeutics in Alzheimer's disease...
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Mass Spectrometry
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Metabolic markers accurately diagnose typhoid fever
Researchers have identified a metabolite 'signature' that can accurately distinguish typhoid from other fever-inducing tropical diseases using patient blood samples.
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New method for early screening of colorectal cancer
A highly sensitive method that can detect even the earlier stages of colorectal cancer has been developed by researchers in Japan.
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Creating the ‘google earth’ of tumours
We caught up with Dr Josephine Bunch to find out how NPL are using the Cancer Research Grand Challenge funding & novel imaging techniques to map cancer tumours...
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EU funds research on biofuels and infectious diseases
Biochemist and physician Professor Ivan Dikic and microbiologist Professor Volker Müller are very honoured that their pioneering research projects have been selected for this substantial financial support.
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Breath test could help detect stomach and oesophageal cancers
A test that measures the levels of five chemicals in the breath has shown promising results for the detection of oesophageal and stomach cancers, in a large patient trial.
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The next revolution in stratified medicine: molecular phenotyping with metabolomics
The study of biochemistry provides molecular insights into how the human population ages, how diseases commence and progress, how molecular changes relate to disease remission and relapse, and how humans respond to treatments...
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Advanced techniques and applications of LC-MS in small molecule drug discovery
A key process in drug discovery is the ability to identify new drug candidates by screening chemical libraries of small molecules, natural products or extracts against a biological target and selecting lead compounds with desirable therapeutic effects. Medicinal chemistry has the challenging role of not only ensuring that the chemical…
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Proteogenomic breast cancer study provides insight into potential therapeutic targets
26 May 2016 | By Victoria White, Digital Content Producer
Scientists have completed the first large-scale proteogenomic study of breast cancer, linking DNA mutations to protein signalling...
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Demands in medical automation technology brings two prominent players close
22 April 2016 | By Snehal Chougule, Allied Market Research
Here, Snehal Chougule discusses Trajan's recent investment in automation solution company, LEAP Technologies Inc...
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Researchers identify PHGDH inhibitor to target serine biosynthesis in cancer
8 March 2016 | By Victoria White
Researchers have shown that CBR-5884 was able to inhibit cell proliferation of breast cancer and melanoma cells lines that overexpress PHGDH...
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Analysing recombinant proteins by mass spectrometry
The drug discovery landscape is changing: no longer limited to big pharma, it is now within reach of academics and small consortia alike. Regardless of the setting, drug discovery requirements are always the same: strong biological theory, good chemical starting material and high quality protein samples from which to determine…
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Mass spectrometry and systems biology approaches in drug target discovery
Cells, organs and organisms are complex biological systems consisting of inter-related components that co-operatively work to maintain function and respond to change. Malfunction of any component can lead to pathologies and disease, leading to system-wide changes and subsequent adaptation. Hence, the ability to study and predict system behaviour will considerably…
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Drug Target Review – Issue #4 2015
3 December 2015 | By Drug Target Review
Included in this issue: Biomarkers, Mass Spectrometry, Target Validation, Drug Development, Personalised Medicines, Next-Generation Sequencing, Protein Expression, Companion Diagnostics, and much more...