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Leveraging “omics” for novel microbiome drug concepts
Listen to this episode to discover how microbiomics is being leveraged to translate gut microbiome findings into new therapeutic options.
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Microbiome
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How chronic stress hastens the progression of colorectal cancer
A new study, presented at the United European Gastroenterology, reveals how chronic stress disturbs the balance of gut microbiota and influences CRC progression.
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New methodologies to find microbiome biomarkers
Confounder control and quantitative profiling revealed misleading associations between microbial markers and colorectal cancer development.
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Elevated TMAO levels predict future risk of CKD
Elevated levels of trimethylamine N-oxide levels were a stronger indicator of CKD risk than the well-known risk factors.
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Link identified between bacteria and cancer treatment efficacy
Researchers mapped the bacteria present in over 4000 metastatic tumour biopsies, which could enable the exploration of new treatments.
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Uncovering the functional role of sRNAs in bacterial adaptation
Researchers find how antibiotic treatments influence the microbiota, providing new strategies for preventing antibiotic-induced damage.
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Exact bacterial lineage associated with colorectal cancer pinpointed
Researchers have discovered two distinct lineages of Fusobacterium nucleatum, which has great implications for colorectal cancer screening and therapeutics.
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Bile acids and the microbiome: revolutionising disease approaches
Thousands of bile acids have been discovered, providing new insights into how microbes influence distant organ systems.
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Investigating the intratumoural microbiome in young-onset CRC patients
New insights about young-onset CRC tumour-related bacteria could lead to new diagnostic markers and therapeutic targets.
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Microbiota composition influences respiratory virus susceptibility
The interactions linking intestinal microbiota with the functionality of basally resident alveolar macrophages and severity of infection are revealed.
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Advancing the development of CTLA-4 inhibitors
A new study could result in CTLA-4 inhibitors that promote antitumour responses without causing intestinal diseases, such as colitis.
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Potential biomarker found for inflammatory bowel disease
A new approach called reverse metabolomics has discovered molecules that may serve as a biomarker or a therapeutic target for IBD.
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Microbiotica: transforming medicine with microbiome magic
In this interview, Anne Neville, Director at Microbiotica, elaborates on the significance of the Microbiotica Culture Collection (MCC) and Microbiotica Reference Genome Database (MRGD), which are fundamental to the development of live biotherapeutic medicines.
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Study reveals harmful gut bacteria linked to irregular sleep patterns
New Study from King's College London: Irregular Sleep Patterns Tied to Harmful Gut Bacteria.
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Gut bacterial interactions limit antibiotic efficacy on C. difficile
A recent study from the University of Wisconsin-Madison suggests that interactions between gut bacteria can influence the effectiveness of antibiotics against C. difficile infections.