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Researchers discover mechanism behind severe cases of G6PD deficiency
Researchers have revealed how the most severe cases of G6PD deficiency occur, which could help scientists design new drugs for the disease.
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Novel human alveolar tissue model could help COVID-19 drug development
Researchers will use the in vitro model to study how respiratory viruses, like SARS-CoV-2, cause Acute Respiratory Distress Syndrome (ARDS) and develop potential interventions.
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Revealed structure of diarrhoea virus could aid in vaccine development
Using cryo-electron microscopy, researchers have observed the structure of a diarrhoea enteric adenovirus to see how it can survive the stomach.
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Atomic force microscopy reveals structure of ribosome stalk proteins
Researchers have used force atomic microscopy to show the structural dynamics at ribosome stalk proteins when building new proteins.
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Blood vessel damage likely causes neurological symptoms of COVID-19, finds study
A new study suggests that inflammation and blood vessel damage may be the primary causes of neurological symptoms in COVID-19 patients, instead of the virus infecting the brain.
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Microscopy reveals four classes of SARS-CoV-2 neutralising antibodies
Researchers show that neutralising antibodies targeting the SARS-CoV-2 Spike protein have four distinct structures.
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Researchers discover how SARS-CoV-2 reaches the brain
A new study has identified the mechanisms through which the SARS-CoV-2 virus enters the brain and how the immune system responds once it does.
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Product hub: Vi-CELL BLU cell viability/counting analyser
The Vi-CELL BLU automates the widely accepted trypan blue dye exclusion method for cell viability that has historically been performed with a light microscope, pipette, and a hemacytometer.
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Novel imaging technique captures multiple tissues in 3D
A new imaging method called FLASH can provide a visualisation of several tissue types in a 3D format, its developers say.
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The latest pre-clinical HIV vaccine developments
This article lists three of the most recent advances in pre-clinical HIV research and vaccine development.
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New insight to guide discovery of drugs targeting ion channels
The study shows how drug-like small molecules inhibit the activity of Transient Receptor Potential Canonical 1/4/5 (TRPC1/4/5) channels and could transform the development of future therapies.
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3D view of SARS-CoV-2 replication cycle could enable antiviral drug development
Scientists have shown how SARS-CoV-2 induces changes in the architecture of host cells to drive replication and made their data available to all.
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Scalable method to image protein levels and changes developed
Using a new CRISPR-Cas9 tagging strategy, researchers have developed a method that enables the imaging of hundreds of proteins in parallel.
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Acquiring structural data on membrane proteins – a spotlight on GPCRs
Lan Zhu from Arizona State University explains how cryo-EM methods can be used to obtain structural information on membrane proteins such as GPCRs.
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ebook: Phenotypic screening with iPSC-derived cardiomyocytes and neurons
Identify therapeutic effects and adverse responses to compounds earlier in the drug discovery process.