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Application note: Hyperion+ imaging system
A powerful tool to study complex phenotypes and cellular interactions. Map spatial interactions twice as fast with this second-generation system.
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Microscopy
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Microscopy technique reveals hidden nanostructures in cells and tissues
Researchers have developed a novel microscopy technique to make invisible molecules visible by “de-crowding” to expand a cell or tissue sample before labelling the molecules.
news
First captured image of antigen-bound T-cell receptor at near-atomic resolution
Using cryo-electron microscopy, researchers have captured the structure of a membrane-bound T-cell receptor complex with bound antigen.
article
A new 3D tool for measuring intracellular lipid droplets
Researchers have developed a novel label-free method named tomographic phase microscopy in flow cytometry for measuring intracellular lipid droplets in 3D.
news
A new study has highlighted how an antibody strengthens bonds between cells
The monoclonal antibody 19A11 binds E-cadherin, a protein that helps cells stick together, especially in epithelial layers that line the skin, the gut and other organs.
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Application note: LlaMAbody™ camelid antibodies flyer
Single-domain antibodies (sdAb) are small, stable antibodies derived from camelids with a single monomeric variable domain.
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Scientists capture first images of an autoantibody attacking a neuron receptor
Researchers for the first time have captured images of an autoantibody bound to a nerve cell surface receptor, revealing the physical mechanism behind a neurological autoimmune disease.
news
Visualising mRNA molecules in the brains of living mice
Scientists have developed a new imaging technique that allows researchers to see gene expression and mRNA molecules in the brains of live mice in real time.
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Scientists discover the key to hepatitis A virus replication
With no current treatments for hepatitis A, scientists have discovered how a protein and enzymes interact to allow hepatitis A virus to replicate.
podcasts
Episode 10 – Microscopy in neuroscience with Dr Tobi Langenhan, Leipzig University & Dr Abdullah Ahmed, Leica Microsystems
Listen along as experts explore some applications of microscopy in neuroscience and discuss common challenges and considerations.
news
Using microscopy to understand how bacteria spreads and multiplies
Researchers have been using state-of-the-art microscopy to analyse bacteria’s shapeshifting behaviour, findings which could lead to treatments for UTIs.
article
The bigger picture: innovation in microscopy
A broader view of cellular processes during the drug discovery and development stages enabled by microscopy could help scientists to design better therapies for patients. In this interview, Drug Target Review’s Victoria Rees asks Dr Peter O’Toole, Head of Imaging and Cytometry at the University of York, UK about his…
article
The promise of cryo-electron tomography
In this exclusive Q&A, Drug Target Review’s Ria Kakkad spoke with Dr Michael Grange, Tomography Group Leader from the Rosalind Franklin Institute (RFI), UK about the advantages of using cryo-electron tomography imaging.
article
A multi-step analysis including GCI reveals novel insight into LPS translocation
Antibiotic resistance is one of the key health challenges of the future. In a new study, researchers have carried out a multi-step analysis to deliver insights into translocation of the hydrophobic and hydrophilic portions of the large lipopolysaccharide molecules through the outer membrane of Neisseria gonorrhoeae. This article summarises their…
news
Gene discovery indicates motor neurone diseases caused by abnormal lipid processing in cells
A new genetic discovery adds weight to a theory that motor neurone diseases are caused by abnormal lipid processing pathways inside brain cells.