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Relationships between SLCs and cytotoxic drugs in human cells uncovered
A new systematic investigation on the role of solute carriers could lead to further insights into how the transporters affect the uptake and activity of drugs.
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Molecular Biology
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Clusterin proteins’ cleanup mechanism is identified
The body’s means of maintaining health are diverse and plentiful, and now researchers in Japan have identified another metaphorical string to its bow: the ability to prevent cell damage using cleanup clusterin proteins that channel damaged proteins for disposal.
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Molecular ‘switch’ could help treat or reverse age-related diseases
A molecular 'switch' that controls the immune machinery responsible for chronic inflammation has been identified which could help treat or even reverse the development of age-related conditions like Alzheimer's, Parkinson's, cancer and diabetes.
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Molecule of blood found to be effective against lupus
Scientists have found that a molecule present in our blood, called C4BP (β-), could be used in a therapeutic capacity for lupus as well as potentially other autoimmune disorders.
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Normal liver cells may have the potential to kill cancer cells
A new discovery that healthy liver tissue surrounding a tumour activates a defence mechanism that restrains tumour growth could inspire new therapeutic approaches that mobilise normal cells to kill cancer cells.
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New molecular drivers of Parkinson’s disease uncovered
Molecular drivers of Parkinson's disease have been revealed by scientists who also determined how they impact the functions of genes involved in the condition and the results may point to potential new treatments.
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CNS tumour aggressiveness reduced with new molecule
A microRNA inhibitor has been identified which reduced the sizes of aggressive CNS tumours and improved survival in mice.
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Regeneration mechanism could provide target for liver disease drugs
A newly-discovered molecular mechanism that allows damaged adult liver cells to regenerate could pave the way for drugs for chronic liver diseases.
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Weapon bacteria could be copied to create new forms of antibiotics
New antibiotics could be designed by discovering the mechanism a weapon bacteria uses to vanquish their competitors.
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T cell homing beacons for lungs identified by researchers
Molecules that are critical for T cells to travel to and populate the lungs have been identified which could strengthen vaccines against influenza.
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Dysfunctional insulin release mechanism identified
A mechanism has been identified which regulates the release of insulin from β-cells and could be used to develop new treatments for type 2 diabetes.
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New target for regulating mitochondria during stress identified
A new target has been identified for the treatment of heart failure, heart attack, stroke and neurodegeneration.
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Designing proteins from scratch with computer science
Marc Baiget-Francesch highlights interesting developments in the field of protein drug design and explains how continual software improvements are speeding up the process.
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Molecule discovered that regulates development of tumours
Researchers discover that a non-coding region of the genome originates a key molecule for the proliferation of cancerous tumours.
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Bringing native analysis into the fast-moving world of biologics
For the past thirty years, native mass spectrometry has grown in both scope and reach in labs across the globe to encompass larger and more challenging molecular complexes. However, up until now, the throughput of these techniques has been slow and manual. Christopher Nortcliffe discusses ways that native analysis is…
