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Final numbers are in: 42 million protein molecules in a yeast cell
Researchers have officially revealed the abundance of protein molecules in a single cell runs into the tens of millions: around 42 million, to be precise.
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Molecular Biology
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Researchers identify new melatonin-based molecular targets for design of new drugs against Parkinson’s
A team of scientists has published the results of a new breakthrough in molecular mechanisms of the anti-parkinsonian activity of melatonin.
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NIH researchers report first 3D structure of DHHC enzymes
The 3D structure of DHHC proteins has been detailed for the first time, explaining how they function and potentially offering a blueprint for designing therapeutic drugs.
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Video: PerkinElmer signals lead discovery
Quickly gain new insights into chemical and biomolecular research data. Featuring guided search and analysis workflows and dynamic data visualisations.
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Proteogenomics research – on the frontier of precision medicine
Proteogenomics is the systematic and comprehensive integration of proteomics with genomics and transcriptomics. Proteogenomics is opening new hallmarks in biomedical research. Recently, several studies have demonstrated the relevance of proteogenomics in cancer research. This article provides a brief review of the advantages of proteogenomics in precision medicine.
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Lung tumours communicate with bones to progress disease
Scientists at Massachusetts General Hospital (MGH) have identified how a type of lung cancer co-opts a portion of the immune system via bone marrow to increase tumour progression.
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SBP scientists uncover mechanism for blood vessel regeneration
A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) has identified a signalling pathway that is essential for angiogenesis, the growth of new blood vessels from pre-existing vessels.
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Immune system can be modulated by targeted manipulation
Manipulation of the sugar metabolism and associated modulation of the immune system could open up new options for treating specific infectious and also autoimmune diseases...
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CRISPR identifies essential genes for cancer immunotherapy
Researchers have used CRISPR to stop the expression of individual genes in cancer cells, by knocking out every known protein-encoding gene in the human genome...
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CRISPR-Cas9 repairs genetic mutation in human embryos
"Well thought through and brilliantly executed" study shows different DNA-repair mechanism in embryos compared to iPSCs
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Study sheds light on how ovarian cancer spreads
Long-term goal is to develop treatments that prevent cancer cells from attaching to new sites during metastasis.
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Application note: The reliability of assay-ready plates for cell-based screening enabled by the Echo® 550 Liquid handler
In this application note, Sheraz Gul (Fraunhofer-IME SP), Markus Wolf (Fraunhofer-IME SP), Enda O’Connell (National University of Ireland Galway) and Howard Fearnhead (National University of Ireland Galway), demonstrate that the Echo 550 Liquid Handler can precisely and accurately transfer nanolitre volumes of compound with acoustic energy in a completely contact-free…
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Snake venom might provide a safer antiplatelet drug
In preliminary research, an antiplatelet drug based on a snake venom protein prevented blood clotting without leading to excessive bleeding, a dangerous side effect of currently available antiplatelet drugs. The venom protein may be the template for a new class of antiplatelet drugs that offers fewer bleeding complications.
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The gut microbiota plays key role in diabetes treatment
A clearer picture of how the classic diabetes medication metformin works has emerged.
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Flexible new method for early cancer diagnosis
Investments are now being made to roll out this innovation across healthcare and broaden the scope of the research in this field.
