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CRISPR identifies essential genes for cancer immunotherapy
Researchers have used CRISPR to stop the expression of individual genes in cancer cells, by knocking out every known protein-encoding gene in the human genome...
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Molecular Biology
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CRISPR-Cas9 repairs genetic mutation in human embryos
"Well thought through and brilliantly executed" study shows different DNA-repair mechanism in embryos compared to iPSCs
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Study sheds light on how ovarian cancer spreads
Long-term goal is to develop treatments that prevent cancer cells from attaching to new sites during metastasis.
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Application note: The reliability of assay-ready plates for cell-based screening enabled by the Echo® 550 Liquid handler
In this application note, Sheraz Gul (Fraunhofer-IME SP), Markus Wolf (Fraunhofer-IME SP), Enda O’Connell (National University of Ireland Galway) and Howard Fearnhead (National University of Ireland Galway), demonstrate that the Echo 550 Liquid Handler can precisely and accurately transfer nanolitre volumes of compound with acoustic energy in a completely contact-free…
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Snake venom might provide a safer antiplatelet drug
In preliminary research, an antiplatelet drug based on a snake venom protein prevented blood clotting without leading to excessive bleeding, a dangerous side effect of currently available antiplatelet drugs. The venom protein may be the template for a new class of antiplatelet drugs that offers fewer bleeding complications.
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The gut microbiota plays key role in diabetes treatment
A clearer picture of how the classic diabetes medication metformin works has emerged.
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Flexible new method for early cancer diagnosis
Investments are now being made to roll out this innovation across healthcare and broaden the scope of the research in this field.
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DFG €66 million funding for 15 new research training groups
The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) is establishing 15 new Research Training Groups to further support early research...
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Researchers find key molecule that could lead to new anaemia therapies
Researchers find key molecule that could lead to new therapies for anaemia and other iron disorders.
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Lung study in mice points to new therapies to treat critical illness
Scientists have pinpointed a chemical signal that worsens inflammation linked to a life-threatening lung condition. The discovery could eventually lead to new therapies for this disease, which can be fatal for up to half of those affected.
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Regenerating bone and cartilage tissues from apple waste
Researchers from UPM and CSIC have employed waste from the agri-food industry to develop biomaterials that are able to act as matrices to regenerate bone and cartilage tissues, which is of great interest for the treatment of diseases related to ageing.
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£10 million pancreatic cancer research fund for precision medicine
The development of new treatments for pancreatic cancer is set to be transformed by a network of clinical trials, aiming to find the right trial for the right patient, after a £10 million investment from Cancer Research UK.
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TSRI scientists use ligands to turbocharge drug discovery
Ligands are useful tools for studying how proteins work in cells and could lead to the development of new drugs.
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DiscoverX HitHunter® cAMP Assays
21 December 2016 | By DiscoverX Corporations
Optimized Assays for a Multitude of GPCR Applications...
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Signalling mechanism for zebrafish fin regeneration identified
4 August 2016 | By Tokyo Institute of Technology
Certain species of amphibians and fish have the remarkable ability to regenerate tissue. Advances in molecular biological analyses have allowed researchers to identify specific molecules and signalling mechanisms involved in tissue regeneration. Fgf signalling is one such key mechanism...