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Novel streamlined screening method could discover new horizons in chemical reaction design
An in-silico reaction screening strategy could produce compounds potentially useful for novel drug development.
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Molecular Biology
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Scientists have identified novel molecular biomarkers in cells that spread triple-negative breast cancer
The researchers identified key molecular differences between triple-negative breast cancer cells that cling to an initial tumour and those that venture off to form distant tumours.
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Novel insights into the genetic and molecular machinery that causes Alzheimer’s disease
Researchers have gained a clearer understanding of the genetic and molecular machinery in human microglia, findings that may provide insight into Alzheimer’s diseases development.
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Newly identified compound reduces potency of Shiga toxin
Scientists have identified a molecule that can bind to a lethal subtype of the bacterial Shiga toxin, suppressing its deadly effects.
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Researchers halt the growth of multiple myeloma in mice
Scientists from Stanford University have been able to halt the growth of multiple myeloma and diffuse large B cell lymphoma in mice with custom molecule sBCMA-Fc V3.
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Researchers use graphene for same-time, same-position biomolecule isolation and sensing
The study has highlighted an important advance in using graphene for electrokinetic bio-sample processing and analysis.
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Chemokines work undercover as drivers of autoimmune disease
New research has uncovered a hitherto unknown mechanism whereby chemokines form DNA-bound nanoparticles that play a key role in autoimmune disorders.
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Scientists develop new graphene imaging technique for clearer pictures of small molecules
Scientists have created a new imaging technique with graphene which generates clearer pictures of the structures of small molecules.
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Key protein identified that helps turn pancreatic cancer cells into a more aggressive form
A new study has shown that it is possible to reverse key process that allows pancreatic cancer cells to grow and spread around the body.
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Immune molecules from a llama could provide protection against COVID-19
Researchers have shown that tiny, robust immune particles derived from a llama’s blood could provide strong protection against every COVID-19 variant.
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Scientists identify the molecular mechanisms behind learning and memory
Researchers identify how acetylcholine sets off a signal cascade in brain cells that directly influence aversive learning and memory formation. The findings may open door to new therapeutic strategies for Alzheimer’s disease.
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Promising anticancer molecule identified
Researchers have identified a DNA-derived molecule that binds to and inhibits the function of CYP24 and shows promising antiproliferative activity.
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NRG Therapeutics to develop small molecule disease-modifying medicines for debilitating chronic neurodegenerative disorders
NRG is developing a pipeline of brain-penetrant small molecule inhibitors of the mitochondrial permeability transition pore (mPTP) with potential as first-in-class treatments for Parkinson's disease and motor neuron disease.
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An effective and error-free gene editor
Scientists have developed a new gene editor which uses a modified pair of molecular scissors that make nicks on opposite strands of the DNA at two different points.
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Scientists discover new molecule that kills hard-to-treat cancers
Scientists have synthesised a new molecule that could kill a broad spectrum of hard-to-treat cancers, including triple-negative breast cancer, by exploiting a weakness in cells not previously targeted by other drugs.