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Plant-derived antiviral drug could combat Delta variant
A novel antiviral drug called thapsigargin (TG) blocked COVID-19 infection in cells, including all new variants, in a pre-clinical study.
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Molecular Biology
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Single molecule from plant used by Native Americans may treat diarrhoea
Scientists unveil the role of KCNQ2/3 using a functional screen of 40 native US plants and identify nine extracts that could treat diarrhoea.
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Drug intended to treat Alzheimer’s may hold promise for glioblastoma
Verubecestat demonstrated poor results in Alzheimer's trials, but helped suppress tumours in pre-clinical glioblastoma models.
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Scientists reveal ultrastructure of Huntington’s disease
Researchers used advanced microscopy and proteomics to unveil new findings on Huntington's disease and open avenues to future treatments.
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Prozac could be repurposed to treat age-related macular degeneration
Fluoxetine - best known as Prozac - protected the macula from inflammation and degeneration in mice and could become a future treatment.
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UTX gene mutation “robs” individuals of natural cancer protection
The UTX gene mutation was found to lead to an increased cancer risk, presenting a potential drug target for preventative therapies.
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Scientists explore CA2 neuron mitochondria for memory loss targets
The team will receive $2 million over five years to investigate the CA2 brain region for the development of neurological therapies.
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Novel intestine chip enables effective in vitro study of COVID-19 therapies
The intestine chip was infected with a coronavirus to test a variety of drugs, presenting a new method to investigate COVID-19 treatments.
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Fruit flies could unveil new genetic targets for obesity treatment
Researchers used obese fruit flies to analyse how gene activities affect triacylglyceride levels, unveiling novel drug targets for obesity.
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Pathway and enzyme responsible for CKD thrombosis identified
Scientists have discovered a novel pathway and enzyme that causes thrombosis in chronic kidney disease (CKD) patients, indicating a new drug target.
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Raman spectroscopy used to determine immunotherapy effectiveness
Researchers used Raman spectroscopy to monitor immunotherapy response in mice, potentially improving cancer treatments in the future.
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Experimental mouse model reveals potential progeria treatment strategy
Scientists have found that Hutchinson-Gilford Progeria Syndrome (HGPS) can be prevented with treatments targeting the cardiovascular system using a novel mouse model.
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Molecular targets for breast cancer relapse identified in new study
German, Norwegian and British scientists have identified molecular targets for therapies that could prevent breast cancer recurrence.
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New antibiotic a possible alternative to treat Lyme disease
The antimicrobial hygromycin A was shown to clear Lyme disease in mice, representing a promising therapeutic against the disease.
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Senescent cell treatment could combat age-related diseases
Scientists have developed a novel technique for the targeted clearance of senescent cells to improve treatments for ageing and other conditions.