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GRP78 molecular chaperone revealed as drug target for COVID-19
Using computer modelling, a team has shown that a molecular chaperone called GRP78 could be targeted by drugs in strategies to treat COVID-19.
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Molecular Modelling
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Fragment screening used to identify potential SARS-CoV-2 antivirals
Researchers have used fragment screening alongside computational docking to reveal 20 hit antiviral compounds against SARS-CoV-2.
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COVID-19 viral envelope simulation under development
Researchers are working to build a complete, all-atom model of the exterior of the coronavirus to aid in drug design.
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Where could bioengineering and technological advances take drug discovery?
Drug Target Review explores the findings of a recent review of molecular, cellular, multi-cellular and tissue engineering and modelling technologies for drug design.
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Novel technique creates complex synthetic drug molecules
A new method has been developed by researchers to create synthetic molecules which replicate natural structures and have potential medicinal uses.
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Carbon hydrogen functionalisation could provide new route for synthesising compounds
The carbon hydrogen functionalisation process could be used to make 3D scaffolds for pharmaceutical compounds, say researchers.
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Richard Goodwin joins DTR Advisory Board
Dr Goodwin is the latest top-level scientist to join DTR's advisory board
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How receptors for medicines work inside cells
G protein-coupled receptors are the key target of a large number of drugs, scientists have now been able to show more precisely how these receptors act in the cell interior...
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Flexible new method for early cancer diagnosis
Investments are now being made to roll out this innovation across healthcare and broaden the scope of the research in this field.
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DFG €66 million funding for 15 new research training groups
The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) is establishing 15 new Research Training Groups to further support early research...
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Researchers find key molecule that could lead to new anaemia therapies
Researchers find key molecule that could lead to new therapies for anaemia and other iron disorders.
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Lung study in mice points to new therapies to treat critical illness
Scientists have pinpointed a chemical signal that worsens inflammation linked to a life-threatening lung condition. The discovery could eventually lead to new therapies for this disease, which can be fatal for up to half of those affected.
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Regenerating bone and cartilage tissues from apple waste
Researchers from UPM and CSIC have employed waste from the agri-food industry to develop biomaterials that are able to act as matrices to regenerate bone and cartilage tissues, which is of great interest for the treatment of diseases related to ageing.
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High-throughput screening platforms incorporating physiologically relevant 3-D models
Two-dimensional monolayer cell proliferation assays for cancer drug discovery have enabled large-scale screens. But they represent a simplified view of oncogenes or tumour suppressor genes as the genetic drivers of cancer cell proliferation.
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A*STAR and MSD team up to advance peptide therapeutics
19 July 2016 | By Niamh Louise Marriott
A*STAR and MSD have formed a two year collaboration aimed at improving cellular delivery of macrocyclic peptides...