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‘Zombie cells’ may hold answer to spinal cord injury recovery
Portuguese researchers propose targeting senescent cells in zebrafish and mammals could lead to developments in human spinal cord injury repair.
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Molecular Targets
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Novel gene therapy for heart failure moves closer to clinic
New research by US institutions in pigs shows that knocking down a particular signalling pathway after heart failure renews heart tissue.
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Nanosized molecules inhibit formation of plaques related to Alzheimer’s
In brain tissues, researchers have shown that two different nanosized polyoxoniobate molecules can inhibit the assembly of amyloid plaques.
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Exome sequencing reveals genetic drug target for OCD
Following a whole exome sequencing study, researchers have found that mutations in the SLITRK5 gene could be targeted by drugs to treat OCD.
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Synthetic antibody treats congenital myasthenia in mice
Researchers have designed an antibody that attaches to MuSK, which prevented early lethality of mice with congenital myasthenia.
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Structural changes in SARS-CoV-2 Alpha and Beta variants revealed
A study has uncovered previously unknown properties of the Spike protein from the SARS-CoV-2 Alpha and Beta variants.
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Study of liver cancer reveals MAGEA3 gene as new drug target
A study has shown that blocking the gene expression of MAGEA3 in liver cancer cells prevents the tumour from proliferating.
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New class of compounds found to block coronavirus reproduction
In cell cultures, a compound named STM2457 was shown to interfere with coronavirus replication, making it a potential treatment for SARS-CoV-2.
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Covalent fragment screening in cell-based phenotypic models of disease: a collaborative approach
The application of chemical perturbation approaches in phenotypic models is often used to identify protein targets for therapeutic discovery. Increasingly, small molecule fragments which covalently bind to their protein targets are being used to explore the druggable proteome and the resulting fragment‑protein interactions are characterised by chemoproteomic techniques. In this…
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The potential of epigenomic medicine in cardiology
Advances in genomic medicine are playing an increasingly important role in the field of cardiology. Better analysis and understanding of patient genomic and epigenomic information can enable more personalised patient treatment and medical intervention. Here, Professor John Giannios considers the potential to use genomic medicine to prevent, monitor, diagnose and…
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Intestinal bacteria found to produce SARS-CoV-2-inhibiting compounds
Researchers have screened bacteria in the gut, finding that Bifidobacteria have inhibitory activity against SARS-CoV-2.
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Nanodecoy therapy neutralises SARS-CoV-2 in macaques
Lung spheroid cells can act as nanodecoys for the SARS-CoV-2 Spike protein to bind to, according to a new pre-clinical study.
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Targeted drug found to combat certain pancreatic tumours
Researchers have found that the CDK inhibitor AT7519 could be used to treat pancreatic cancer patients whose tumours are addicted to mutant KRAS.
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Human cells can write RNA sequences into DNA, study shows
For the first time, scientists have found evidence that polymerase theta can write RNA segments back into DNA.
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Study provides clues to cause and possible treatment of Parkinson’s
Researchers have shown that the leakage of mitochondrial double-stranded DNA into the cell can contribute to Parkinson's disease.
