news
Researchers synthesise potential anticancer compounds
Scientists have developed six new derivatives of 4-chloro-1,2-dithiol-3-thione, which have all demonstrated anticancer effects in pre-clinical studies.
List view / Grid view
Molecular Targets
news
WHO and Switzerland launch BioHub for pathogen storage and analysis
The WHO and Swiss Confederation are set to launch a BioHub Facility, intended to facilitate the sharing of pathogens globally.
news
GRP78 molecular chaperone revealed as drug target for COVID-19
Using computer modelling, a team has shown that a molecular chaperone called GRP78 could be targeted by drugs in strategies to treat COVID-19.
news
Scientists identify protein drug target to potentially treat cataracts
Researchers have shown that a protein named aquaporin can disrupt optical development, leading to cataract formation.
news
Genomic analysis reveals cellular cause of type 1 diabetes
Combining two genomic methodologies, researchers have shown that pancreatic exocrine cells are implicated in type 1 diabetes.
article
Millennia in the making: unlocking the medicinal value of CBD
Dr Sotirios Karathanasis discusses the history of cannabis as a treatment and delves into the process of turning plant-based medicines into clinically proven drugs.
news
Novel method of labelling DNA bases developed for sequencing
Using electrochemical detection and redox labels, researchers have created a new, faster method to sequence DNA.
news
Novel inhibitor blocks myeloma cancer cell growth in mouse model
Having identified the histone demethylase KDM5A as a multiple myeloma target, researchers developed a KDM5 inhibitor to treat the cancer.
news
Lipid droplets may prevent kidney damage from high-fat diets
Researchers have shown in fruit flies that lipid droplets could prevent the kidney damage that leads to chronic kidney disease.
news
Protein associated with Lyme disease arthritis discovered
A team has shown that the NapA protein, associated with Lyme disease, attracts inflammatory molecules in the body.
news
Researchers reveal frameshifting as SARS-CoV-2 drug target
A critical stage of the SARS-CoV-2 replication process, known as frameshifting, could be targeted by new drugs, researchers say.
news
Mitochondrial enzyme found to block ferroptosis, presenting cancer target
The mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) can block cell death, new research has shown, making it a cancer drug target.
news
Scientists design new drug compound to combat malaria
Researchers have developed a set of compounds designed to stop the malaria parasite being able to burst out of red blood cells and replicate.
news
Small molecule screens reveal new class of anticancer compounds
Two screening techniques were used by researchers to find anticancer compounds that target the aryl hydrocarbon receptor.
news
Second mechanism of action discovered for COVID-19 drug remdesivir
Researchers have found that a metabolite of remdesivir potentially targets a SARS-CoV-2 protein involved in suppressing the host cell's defence response.