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GRP78 molecular chaperone revealed as drug target for COVID-19
Using computer modelling, a team has shown that a molecular chaperone called GRP78 could be targeted by drugs in strategies to treat COVID-19.
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Molecular Targets
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Scientists identify protein drug target to potentially treat cataracts
Researchers have shown that a protein named aquaporin can disrupt optical development, leading to cataract formation.
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Genomic analysis reveals cellular cause of type 1 diabetes
Combining two genomic methodologies, researchers have shown that pancreatic exocrine cells are implicated in type 1 diabetes.
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Millennia in the making: unlocking the medicinal value of CBD
Dr Sotirios Karathanasis discusses the history of cannabis as a treatment and delves into the process of turning plant-based medicines into clinically proven drugs.
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Novel method of labelling DNA bases developed for sequencing
Using electrochemical detection and redox labels, researchers have created a new, faster method to sequence DNA.
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Novel inhibitor blocks myeloma cancer cell growth in mouse model
Having identified the histone demethylase KDM5A as a multiple myeloma target, researchers developed a KDM5 inhibitor to treat the cancer.
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Lipid droplets may prevent kidney damage from high-fat diets
Researchers have shown in fruit flies that lipid droplets could prevent the kidney damage that leads to chronic kidney disease.
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Protein associated with Lyme disease arthritis discovered
A team has shown that the NapA protein, associated with Lyme disease, attracts inflammatory molecules in the body.
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Researchers reveal frameshifting as SARS-CoV-2 drug target
A critical stage of the SARS-CoV-2 replication process, known as frameshifting, could be targeted by new drugs, researchers say.
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Mitochondrial enzyme found to block ferroptosis, presenting cancer target
The mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) can block cell death, new research has shown, making it a cancer drug target.
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Scientists design new drug compound to combat malaria
Researchers have developed a set of compounds designed to stop the malaria parasite being able to burst out of red blood cells and replicate.
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Small molecule screens reveal new class of anticancer compounds
Two screening techniques were used by researchers to find anticancer compounds that target the aryl hydrocarbon receptor.
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Second mechanism of action discovered for COVID-19 drug remdesivir
Researchers have found that a metabolite of remdesivir potentially targets a SARS-CoV-2 protein involved in suppressing the host cell's defence response.
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Epithelial cells found to communicate in two distinct ways
Epithelial cell communication depends on the side of the cell, which could have implications for understanding how cancer spreads.
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Researchers use exosomes to develop potential salmonella vaccine
Exosomes containing salmonella antigens were administered to the mice, enabling the models to develop antibodies against the bacteria.