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Importin-11 identified as new therapeutic target for colorectal cancer
Researchers have discovered that Importin-11, a cell nucleus import protein, is required for colorectal cancer growth and may be a possible target for new therapies.
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Molecular Targets
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Assay for reading six molecular pathways simultaneously developed
Researchers have developed a luciferase assay that can be used to monitor the effects of treatments on six different molecular targets at once.
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Method to coax immune system into selecting HIV antibodies developed
Immunogens can be used to coax the immune system into producing broadly neutralising antibodies to fight a HIV infection, making a vaccine against the condition more likely, say researchers.
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Researchers must not rely on generic online searches for chemical probes, study finds
The ICR has revealed that during drug discovery, researchers should not use general search engines and vendor catalogue information to decide on their use of chemical probes.
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Researchers reveal how fungi produce potential therapeutic compounds
A team has discovered that fungi use the Diels-Alder reaction to assemble new compounds that have potential pharmaceutical uses.
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Key pathway discovered in periodontal ligament maturation
A research team have found a signalling pathway which plays a critical role in the maturation of periodontal ligament, providing information for the development of dental treatments.
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Applying AI language translation to the creation of new pharmaceuticals
Designing new drug molecules is crucial to R&D. Dr Sam Genway suggests that one way to improve and speed up this process is using AI inspired by language translation.
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Synthetic molecules could provide new antibiotics
Using a novel technique, researchers have created new molecules effective at killing bacteria, providing new antibiotic drug targets.
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Next generation molecular medicine: unlocking big data for precision oncology and infectious disease
Join the international [BC]2 conference and EMBO meeting at BASEL LIFE from 9–12 September: a unique opportunity for today’s scientists to get insights and share the latest discoveries, resources and approaches to make sense of genomic and health-related “big data” for molecular medicine – from precision oncology to infectious diseases.
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Scientists find a cellular process that stops cancer before it starts
Salk research shows that cellular recycling process, thought to fuel cancer's growth, can actually prevent it...
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‘Hidden pocket’ could be targeted to treat strokes
Researchers have identified a tiny hidden pocket on the NMDA receptor that could be targeted to treat strokes and seizures...
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Drug sponge could minimise effects of cancer therapy
A drug 'sponge' could be the future method of soaking up excess drugs within the body after cancer treatments such as chemotherapy to prevent side effects...
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New frontiers in G protein-coupled receptor drug discovery
G protein-coupled receptors (GPCRs) are seven transmembrane spanning proteins that mediate the physiological responses to a broad array of stimuli, including photons, biogenic amines, peptides and large proteins. They represent the target of approximately one-third of all approved drugs,1 yet paradoxically remain a relatively under-exploited protein class.
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Expert view: Tackling drug discovery inefficiencies requires diverse libraries, technologies with broader applicability and actionable insights
Inefficiencies in drug discovery are hard to ignore when despite ever-increasing investment in pharmaceutical research and development, the number of new drugs approved by the US Food and Drug Administration (FDA) remains low.
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Application note: A complete next-generation sequencing workflow for circulating cell-free DNA isolation and analysis
Circulating cell-free DNA (cfDNA) has been shown to have potential as a noninvasive substrate for the detection and monitoring of tumour cells. As circulating tumour DNA is often present at low frequencies within cfDNA, targeted sequencing is an optimal tool for mutation detection.