news
Brain changes responsible for the appetite effects of cannabis identified
New research on how cannabis use alters eating behaviour could lead to treatments for appetite loss in chronic illness...
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Molecular Targets
news
Injected VEGF-C could prevent heart failure
Vascular Endothelial Growth Factor C (VEGF-C) could aid the repair and recovery of hearts after a heart attack, by enabling immune cells to clear dead and dying cells...
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Bioactivity profiling supporting the progression of phenotypic hits
Addressing the optimisation of hits derived from a target-agnostic phenotypic screen, using a strategy based on combining bioactivity profiling and reference compound characterisation...
whitepaper
Application note: Real-time detection of Gs and Gi Signalling in living cells
Genetically-encoded biosensors from Montana Molecular allow for detection of GPCR signalling...
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Cancer protein NEDD9 plays a critical role in PAH
Study identifies cancer protein as a target for treating fibrosis of the lung arteries with direct implications for patients with pulmonary arterial hypertension...
news
Alpha-synuclein clumps promote Parkinson’s progression
Detailed brain cell analysis has helped researchers uncover new mechanisms thought to underlie Parkinson's disease...
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Artificial gene defect reveals target to fight genetic disease
Scientists have deployed a novel genetic screen to search for synthetic viable interactions on special lines of Fanconi Anaemia-defective cells...
article
Transforming translational research: CANscriptTM – a better predictive model for oncology
This webinar focused on a recent study evaluating a cohort of head and neck squamous cell carcinoma (HNSCC) patient tumours treated with anti-PD1 using CANscript™.
article
Supporting the progression of phenotypic hits with bioactivity profiling
Bioactivity profiling has been traditionally used to assess the selectivity of new drug candidates in the context of target-based approaches, where pharmacological selectivity is a key requirement.
news
Link between TB and Parkinson’s disease identified
The mechanism our immune cells use to clear bacterial infections like tuberculosis might also be implicated in Parkinson's disease...
webinar
Transforming translational research: CANscriptTM – A better predictive model for oncology
27 April 2018 | By Mitra Biotech
In this webinar, speaker Mark Paris, PhD discussed a recent study evaluating a cohort of HNSCC patient tumours treated with anti-PD1 using CANscript TM;. He also be reviewed the results of this study as a means of investigating predictors of clinical response and identifying mechanisms of resistance.
webinar
Using bioactivity profiling to support the progression of phenotypic hits
27 April 2018 | By Eurofins Pharma Discovery Services
In this webinar, we discussed a recent case study where a phenotypic screen was performed using poly I:C / IL-4 stimulated human bronchial epithelial cells. This resulted in the identification of 7 representative hits which provided starting points for new drug discovery opportunities.
news
New method allows scientists to watch brain cells interacting in real time
Findings could deepen understanding of neurological disorders...
news
Ultrathin endoscope captures neurons firing deep in the brain
A new fibre-based endoscope, tested in mice, poised to bring new insights into brain function...
news
Extracellular vesicles could be personalised drug delivery vehicles
Researchers developed an approach and platform to create large amounts of fillable and targeted nanovesicles to deliver drugs to tumours in mice...