Molecular Targets

Researchers use CRISPR-Cas9 to target retinal angiogenesis.

25 July 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have used CRISPR-Cas9 to target retinal angiogenesis via an adeno-associated virus to deliver genomic edits to target vascular endothelial cell growth factor...

Intracellular target validation in cellular systems … using peptides!

7 July 2017 | By Paul Grant (Venomtech)

Paul Grant from Venomtech suggests that because animal venoms contain proteins and peptides that disrupt cell membrane integrity, they offer a new approach to drug discovery...

Study sheds light on how ovarian cancer spreads

28 June 2017 | By Niamh Marriott (Drug Target Review)

Long-term goal is to develop treatments that prevent cancer cells from attaching to new sites during metastasis.

Collaboration uses novel approach to identify antibacterial drug targets

27 June 2017 | By Drug Target Review

LifeArc, the UK medical research charity previously known as MRC Technology; The Centre for Drug Research and Development (CDRD); and the Defence Science and Technology Laboratory (Dstl), have announced a collaboration to identify antibacterial drug targets.

Snake venom might provide a safer antiplatelet drug

9 June 2017 | By Niamh Marriott (Drug Target Review)

In preliminary research, an antiplatelet drug based on a snake venom protein prevented blood clotting without leading to excessive bleeding, a dangerous side effect of currently available antiplatelet drugs. The venom protein may be the template for a new class of antiplatelet drugs that offers fewer bleeding complications.

The gut microbiota plays key role in diabetes treatment

2 June 2017 | By Niamh Marriott (Drug Target Review)

A clearer picture of how the classic diabetes medication metformin works has emerged.

GE Healthcare Ltd

Flexible new method for early cancer diagnosis

25 May 2017 | By Niamh Marriott (Drug Target Review)

Investments are now being made to roll out this innovation across healthcare and broaden the scope of the research in this field.

DFG €66 million funding for 15 new research training groups

22 May 2017 | By Niamh Marriott (Drug Target Review)

The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) is establishing 15 new Research Training Groups to further support early research...

Researchers find key molecule that could lead to new anaemia therapies

17 May 2017 | By Niamh Marriott (Drug Target Review)

Researchers find key molecule that could lead to new therapies for anaemia and other iron disorders.

Lung study in mice points to new therapies to treat critical illness

10 May 2017 | By Niamh Marriott (Drug Target Review)

Scientists have pinpointed a chemical signal that worsens inflammation linked to a life-threatening lung condition. The discovery could eventually lead to new therapies for this disease, which can be fatal for up to half of those affected.

£10 million pancreatic cancer research fund for precision medicine

24 March 2017 | By Niamh Marriott (Drug Target Review)

The development of new treatments for pancreatic cancer is set to be transformed by a network of clinical trials, aiming to find the right trial for the right patient, after a £10 million investment from Cancer Research UK.

TSRI scientists use ligands to turbocharge drug discovery

23 January 2017 | By Niamh Marriott (Drug Target Review)

Ligands are useful tools for studying how proteins work in cells and could lead to the development of new drugs.

Possible new target for psoriasis identified

13 June 2016 | By Victoria White, Digital Content Producer

A small protein in the skin called Rac1 appears to link well-known environmental triggers of the disease with a genetic predisposition to the condition...

Browsing for drug targets

8 March 2016 | By Edward D. Zanders, PharmaGuide Ltd, Cambridge, UK

Here, Edward D. Zanders explains his motivation behind writing ‘Human Drug Targets a Compendium for Pharmaceutical Discovery’ - a collection of current and potential drug targets mapped to human genes curated by the HGNC...