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Study sheds light on how ovarian cancer spreads
Long-term goal is to develop treatments that prevent cancer cells from attaching to new sites during metastasis.
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Molecular Targets
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Collaboration uses novel approach to identify antibacterial drug targets
LifeArc, the UK medical research charity previously known as MRC Technology; The Centre for Drug Research and Development (CDRD); and the Defence Science and Technology Laboratory (Dstl), have announced a collaboration to identify antibacterial drug targets.
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Snake venom might provide a safer antiplatelet drug
In preliminary research, an antiplatelet drug based on a snake venom protein prevented blood clotting without leading to excessive bleeding, a dangerous side effect of currently available antiplatelet drugs. The venom protein may be the template for a new class of antiplatelet drugs that offers fewer bleeding complications.
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The gut microbiota plays key role in diabetes treatment
A clearer picture of how the classic diabetes medication metformin works has emerged.
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Flexible new method for early cancer diagnosis
Investments are now being made to roll out this innovation across healthcare and broaden the scope of the research in this field.
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DFG €66 million funding for 15 new research training groups
The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) is establishing 15 new Research Training Groups to further support early research...
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Researchers find key molecule that could lead to new anaemia therapies
Researchers find key molecule that could lead to new therapies for anaemia and other iron disorders.
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Lung study in mice points to new therapies to treat critical illness
Scientists have pinpointed a chemical signal that worsens inflammation linked to a life-threatening lung condition. The discovery could eventually lead to new therapies for this disease, which can be fatal for up to half of those affected.
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£10 million pancreatic cancer research fund for precision medicine
The development of new treatments for pancreatic cancer is set to be transformed by a network of clinical trials, aiming to find the right trial for the right patient, after a £10 million investment from Cancer Research UK.
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TSRI scientists use ligands to turbocharge drug discovery
Ligands are useful tools for studying how proteins work in cells and could lead to the development of new drugs.
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Possible new target for psoriasis identified
13 June 2016 | By Victoria White, Digital Content Producer
A small protein in the skin called Rac1 appears to link well-known environmental triggers of the disease with a genetic predisposition to the condition...
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Browsing for drug targets
8 March 2016 | By Edward D. Zanders, PharmaGuide Ltd, Cambridge, UK
Here, Edward D. Zanders explains his motivation behind writing ‘Human Drug Targets a Compendium for Pharmaceutical Discovery’ - a collection of current and potential drug targets mapped to human genes curated by the HGNC...
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Inhibition of 15-PGDH has a positive effect on tissue regeneration
17 June 2015 | By Victoria White
A new study suggests 15-PGDH shows promise as a drug target to help tissue regeneration, particularly after bone marrow transplantation and tissue injuries...
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Molecular Target Validation in preclinical drug discovery
Preclinical drug target validation has the aim to increase confidence in a particular drug target. The process proves the initial hypothesis that a particular molecular target is key or even causative for pathogenic or symptomatic mechanisms in a disease. Several success factors seem to be of particular importance for the…