news
Researchers identify RNA molecule that suppresses prostate tumours
Scientists discover a long noncoding RNA, termed NXTAR, and a small molecule drug that could be used to treat prostate cancer.
List view / Grid view
Molecular Targets
news
Fruit flies could unveil new genetic targets for obesity treatment
Researchers used obese fruit flies to analyse how gene activities affect triacylglyceride levels, unveiling novel drug targets for obesity.
news
Researchers identify COVID-19 proteins that cause blood vessel damage
Scientists revealed five proteins that cause blood vessel damage in COVID-19 patients, potentially leading to new drug targets.
news
Pathway and enzyme responsible for CKD thrombosis identified
Scientists have discovered a novel pathway and enzyme that causes thrombosis in chronic kidney disease (CKD) patients, indicating a new drug target.
news
GLP-1 and GIP receptor agonists reduce mouse obesity in pre-clinical study
Treatment with Viking Therapeutics' dual agonists resulted in mean reductions in body weight of up to 27 percent compared to semaglutide-treated animals.
news
Scientists target ALS and dementia RNA using novel molecule
The small molecule successfully targeted the C9orf72 gene that causes amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
video
Engineering better CAR T cells with Professor Ann Ager, Cardiff University
Watch this exclusive interview with Professor Ann Ager, Cardiff University, to discover how CAR T cells could be targeted against solid tumours.
news
Groundbreaking data tool may uncover novel class of GPCRs
A new computer-aided tool maps allosteric sites in G protein-coupled receptors to search for allosteric drugs to treat a range of diseases.
news
Experimental mouse model reveals potential progeria treatment strategy
Scientists have found that Hutchinson-Gilford Progeria Syndrome (HGPS) can be prevented with treatments targeting the cardiovascular system using a novel mouse model.
news
Specific mechanism found to control transition from acute to chronic pain
A new study is the first to identify N-acylethanolamine acid amidase as a new drug target to treat different forms of chronic pain.
news
Molecular targets for breast cancer relapse identified in new study
German, Norwegian and British scientists have identified molecular targets for therapies that could prevent breast cancer recurrence.
news
Targeting channel in cell lysosome could selectively kill cancer cells
Activating the protein channel TRPML1 induced selective melanoma cell death while sparing normal cells, suggesting a potential pathway for new cancer therapies.
news
Nanofibre platform shows potential for inhibiting brain tumour growth
Scientists have created a nanofibre-based sheet to control and direct the migration of cells, possibly leading to brain tumour therapies.
news
Novel method refines cryogenic electron microscopy (cyro-EM)
The statistical method known as maximum entropy could improve cryogenic electron microscopy (cryo-EM) for more effective drug treatments.
news
Senescent cell treatment could combat age-related diseases
Scientists have developed a novel technique for the targeted clearance of senescent cells to improve treatments for ageing and other conditions.