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Novel nanotherapy offers hope for potential treatment of type 1 diabetes
Researchers have developed rapamycin-loaded nanocarriers capable of targeting cells related to pancreatic islet transplants without suppressing wider immune responses.
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Nanomedicine
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Nanoparticle delivery of CRISPR enables genome editing of vascular endothelium
According to researchers, a new method to deliver CRISPR-Cas9 to vascular endothelial cells could be used to treat many diseases, including COVID-19.
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Targeted nanomedicine reduces vascular lesions in mouse models
The new nanoparticle uses a peptide to target the vascular cell adhesion molecule 1 and reduced the size of vascular lesions in a mouse study.
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Nanobubbles show promise for delivering anti-inflammation treatments
Nanobubbles known as extracellular vesicles (EVs) were shown to deliver protein drugs in animal models with inflammatory diseases.
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Novel class of LPPOs could provide alternative to antibiotics, study shows
Lipophosphonoxins may represent the next generation of antibiotics and can be delivered using a new type of dressing for skin wounds.
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Drug Target Review – Issue 3 2021
In this issue, find articles exploring why CRISPR is useful for high-throughput drug discovery, how targeting telomerase may lead to universal cancer vaccines and a new study to identify therapeutics that can be repurposed against COVID-19. Also included are features on neuroscience, organoids and antibodies.
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New nanotechnology could combat colorectal cancer and melanoma
A nanotherapeutic delivery system displayed high efficacy against metastatic tumours in mice, potentially improving chemotherapy treatments.
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Llama nanobodies could serve as new treatment for HCMV
Scientists have developed a “llama nanobody” that is capable of chasing out human cytomegalovirus (HCMV) so it is detected by the immune system.
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Newly designed tumour vaccine could prevent cancer recurrence
Scientists have used nanotechnology to develop personalised tumour vaccines which prevented cancer recurrence and metastasis challenges in mouse models.
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Nanosized molecules inhibit formation of plaques related to Alzheimer’s
In brain tissues, researchers have shown that two different nanosized polyoxoniobate molecules can inhibit the assembly of amyloid plaques.
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Radiopharmaceuticals and nanoparticles used to kill cancer cells
Researchers have developed a potential cancer treatment using light from radiopharmaceuticals and polymer nanoparticles to kill cancer cells.
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Nanoparticle platform enables enhanced delivery of gene therapies
Scientists have created new nanoparticle-based materials that could be used to deliver gene therapies in an adaptable way.
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Nanoparticle flu vaccine shows promise at protecting mice
Using nanoparticle liposomes, researchers have developed an experimental flu vaccine that has shown success in pre-clinical studies.
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Scientists identify protein drug target to potentially treat cataracts
Researchers have shown that a protein named aquaporin can disrupt optical development, leading to cataract formation.
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Potential COVID-19 antiviral formulated with siRNA-nanoparticles
Scientists have created an antiviral therapy using lipid nanoparticles that deliver siRNA to the lungs to treat COVID-19 in mice.
