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Potential drug target for Alzheimer’s identified
New research has identified an enzyme which causes degradation of dendritic spines, pointing to a drug target for Alzheimer’s.
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Neurons
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Using stem cells to study the effects of cannabis on neuronal development
Thanks to new developments with induced pluripotent stem cells enabling generation of human neurons, scientists can more precisely analyse the effects that chemicals have on human cells. This article describes research into the effects of cannabis on neuronal development and implications of its legalisation in Canada.
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Key gene targeting could lead to treatment for Down syndrome
Researchers use stem cell-based disease models to pinpoint gene linked to impaired memory in Down syndrome.
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Protein phosphorylation inhibition promotes optic nerve regeneration
New findings could be translated into the development of novel treatments for patients with optic neuropathies.
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New study into unlocking the brain’s regenerative potential
Scientists identify 'wake-up' signal for deep-sleeping neural stem cells to potentially aid in the treatment for neurological disorders.
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New role unlocked for nervous system in regeneration
Using a computational model, researchers were able to explain, predict, and manipulate the regeneration of a flatworm body.
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New technology to produce dorsal cortical neurons using iPS
Scientists expect that it will soon be possible to treat brain diseases by restoring damaged areas in the brain by mass producing neurons using stem cells...
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BDNF–VEGF interplay key to rapid antidepressant actions
A study reveals a complex interplay of two different growth factors in the rapid and long-lasting antidepressant effects of ketamine...
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Nuclear tracers help assess new drugs for neurodegenerative diseases
New nuclear medicine tracers could help medical researchers find a cure for Alzheimer's and other neurodegenerative diseases.
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Application note: GABAA Receptors
SB Drug Discovery shows the validation of fluorescence and automated electrophysiology assays designed to assess agonists, antagonists and allosteric modulators of these receptors, culminating in a high-throughput electrophysiology assay suited to assessing multiple GABAA receptor subtypes on a single assay plate.
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Compounds in coffee may fight Parkinson’s
Caffeine plus another compound in coffee beans' waxy coating may protect against brain degeneration...
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MRI scans shows promise in predicting dementia
Brain changes evident in scans before memory, cognitive decline...
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New information on the pathological mechanisms of Alzheimer’s disease
Researchers have indicated that the accumulation of pathological tau triggers a safety valve mechanism in the otherwise well-regulated cell membranes...
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Inhibiting USP13 destroys toxic clumps seen in Parkinson’s disease
A team of neurologists have found that one reason Lewy bodies develop is that a molecule, USP13, has removed all the "tags" placed on alpha-synuclein that mark the protein for destruction...
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Sensory neurons can be used to discover therapies for ALS
New approach for testing for ALS may be useful to reverse debilitating disease...