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Two-week-old human embryos reveal origin of Huntington’s disease
Scientists have discovered a signalling pathway alteration in embryos with Huntington’s disease, paving the way for ground-breaking treatments.
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Nobel Prize for medicine awarded to temperature and touch discoveries
David Julius and Ardem Patapoutian have won the 2021 Nobel Prize for Physiology or Medicine, with their work being used to develop treatments for conditions such as chronic pain.
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Gene therapy method could restore visual function after stroke
Scientists have revealed a way to use gene therapy to turn glial brain cells into neurons, restoring vision and potentially restoring motor function.
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Psilocybin spurs growth of neural connections lost in depression in vivo
Research from Yale University has shown that psilocybin, given to mice, triggered an increase in connections between neurons.
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Promising pre-clinical data announced for Parkinson’s drug
Stealth BioTherapeutics reported positive data from a pre-clinical study evaluating SBT-272 in a murine model of Parkinson's disease.
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Ground-breaking small molecule attenuates neuroinflammation in mice
Limiting neuroinflammation was shown to be a promising approach to treat neurological diseases such as stroke and spinal cord injury in mice.
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An integrated vaccination approach to neurodegeneration
Guided by precise biomarker tests, therapeutic vaccines targeting the pathology of neurodegenerative disease could provide solutions to the impending global crisis in dementia. As Dr Andrea Pfeifer, Co-Founder, Chief Executive Officer and Director of AC Immune, describes here, current work is both establishing the targets that those vaccines must address…
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Investigating neural oscillations in human brain organoids
This article delves into research at the University of California Los Angeles, US, where stem-cell derived brain organoids that can mimic electrical activity have been developed.
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Researchers identify specific drug targets for a variety of brain disorders
Scientists have discovered drug targets in the neural circuits that encode memories, paving the way for the treatment of brain disorders.
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Innovative brain model provides patient-specific Alzheimer’s insights
Researchers have turned human stem cells into brain cells to create a new model that can predict cognitive decline rate on an individualised level.
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Signalling pathway identified as target against paediatric glioma
Researchers have found a vulnerability in a developmental signalling pathway, presenting a target for paediatric low-grade glioma formation.
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Getting “under the skin” of frontotemporal dementia
Researchers at the University of East Finland have been using skin cells to investigate pathological hallmarks in frontotemporal dementia patients.
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Mechanisms behind synapse degeneration in Alzheimer’s unveiled
Researchers have uncovered a signalling pathway associated with glutamatergic synapse degeneration in the brains of mice with Alzheimer’s.
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New study discovers how Parkinson’s-linked protein attacks mitochondria
Researchers have used fruit fly larvae to explore how alpha-synuclein impacts the mitochondria, advancing the study of Parkinson’s disease.
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TREM2 regulation to prevent neurodegeneration is possible, study shows
Scientists used a synthetic thyroid hormone in mice to regulate the TREM2 gene implicated in diseases such as Alzheimer’s and Parkinson’s.