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Neuroprotection

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Researchers discover α-synuclein clue to treating Parkinson’s

17 January 2020 | By Victoria Rees (Drug Target Review)

A study has shown that fruit fly larvae lacking a certain region of the α-synuclein protein did not exhibit Parkinson’s symptoms, indicating a potential target.

news

Alzheimer’s vaccine shows promising results in bigenic mice

3 January 2020 | By Hannah Balfour (Drug Target Review)

Researchers have created a new combination vaccine therapy that can induce strong immune responses against tau and Aβ pathologies seen in Alzheimer’s in bigenic mice.

article

The implication of a dysfunctional proteasome regulator in neurodegenerative disease

13 December 2019 | By Hannah Balfour (Drug Target Review)

Disrupted protein homeostasis from PI31 inactivation may initiate the process of neurodegeneration seen in Alzheimer’s, ALS and other similar diseases, says new research.

news

Nuclear tracers help assess new drugs for neurodegenerative diseases

21 January 2019 | By Dr Zara Kassam (Drug Target Review)

New nuclear medicine tracers could help medical researchers find a cure for Alzheimer's and other neurodegenerative diseases.

news

Compounds in coffee may fight Parkinson’s

11 December 2018 | By Drug Target Review

Caffeine plus another compound in coffee beans' waxy coating may protect against brain degeneration...

news

MRI scans shows promise in predicting dementia

23 November 2018 | By Drug Target Review

Brain changes evident in scans before memory, cognitive decline...

news

New information on the pathological mechanisms of Alzheimer’s disease

21 November 2018 | By Drug Target Review

Researchers have indicated that the accumulation of pathological tau triggers a safety valve mechanism in the otherwise well-regulated cell membranes...

news

Inhibiting USP13 destroys toxic clumps seen in Parkinson’s disease

14 November 2018 | By Drug Target Review

A team of neurologists have found that one reason Lewy bodies develop is that a molecule, USP13, has removed all the "tags" placed on alpha-synuclein that mark the protein for destruction...

news

Sensory neurons can be used to discover therapies for ALS

9 November 2018 | By Drug Target Review

New approach for testing for ALS may be useful to reverse debilitating disease...

news

Brain activity pattern may be early sign of schizophrenia

8 November 2018 | By Drug Target Review

In a study that might enable earlier diagnosis, neuroscientists find abnormal brain connections that can predict the onset of psychotic episodes...

news

Medical marijuana may provide pain relief for chronic nerve pain

6 September 2018 | By zara

When medical marijuana is taken for chronic nerve pain, it may provide pain relief by reducing connections between the areas of the brain that process emotions and sensory signals...

news

Powerful molecules provide new findings about Huntington’s disease

23 August 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers have discovered a direct link between the protein aggregation in nerve cells that is typical for neurodegenerative diseases, and the regulation of gene expression in Huntington's disease...

news

miR-132 offers hope for novel Alzheimer’s treatments

3 August 2018 | By Dr Zara Kassam (Drug Target Review)

The study of neuroprotective microRNAs like miR-132 may lead to new avenues for treating Alzheimer's disease and other tau pathologies...

news

MicroRNA provides promise in search for simple, early test for Alzheimer’s

29 June 2018 | By Drug Target Review

Researchers have found early evidence that tiny snippets of microRNA may help with early detection of conditions such as Alzheimer's disease...

news

Alpha-synuclein clumps promote Parkinson’s progression

14 June 2018 | By Dr Zara Kassam (Drug Target Review)

Detailed brain cell analysis has helped researchers uncover new mechanisms thought to underlie Parkinson's disease...

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