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New research points to a possible driver of Parkinson’s disease
A study has shown how Parkinson’s disease may be driven by cell stress-related biochemical events that disrupt a key cellular clean-up system.
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Neurosciences
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Possible improvement to Parkinson’s disease treatment shown in study
Research from the University of Copenhagen reveals how Deep Brain Stimulation treatment of walking problems in Parkinson’s disease could be optimised by targeting specific neurons in the brainstem.
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Scientists ‘reinvent’ petri dish for growing live brain tissue
Researchers have innovated the petri dish to be able to grow and age live brain cells from patients with neurological disorders.
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Study may be critical step to understanding cognitive disorders
In a scientific first, researchers have discovered fundamental mechanisms by which the hippocampus region of the brain organises memories into sequences and how this can be used to plan future behaviour.
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Research provides potential new way of preventing Alzheimer’s disease
New pre-clinical research from the Université Laval Faculty of Medicine and CHU de Québec–Université Laval Research Centre showed genetically mutating human cells could avoid Alzheimer’s disease.
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Gut-brain pathway metabolite involved in age-related cognitive decline, study shows
In mice, researchers have shown that δ-valerobetaine plays a role in neurocognitive ability, making the metabolite a target for age-related memory loss.
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Brain recordings could improve deep brain stimulation therapy for OCD
Scientists captured more than 1,000 hours of brain recordings from obsessive compulsive disorder (OCD) patients and uncovered candidate neurological signatures.
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Product hub: Stay at the forefront of neuroscience research
Read about our comprehensive portfolio of rigorously developed kits harnessing the ultrasensitive Single Molecule Counting (SMC™) technology.
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Mechanism that causes ALS nerve destruction unveiled for first time
The study reveals the biological mechanism that causes nerve destruction in amyotrophic lateral sclerosis (ALS), potentially leading to treatments that reverse the disease.
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Drug Target Review – Issue 4 2021
This issue includes articles that discuss the development of long-term 3D tissue cultures from human biopsy samples, the application of flow cytometry in drug discovery and automation for upstream processing in a biologics manufacturing environment. Also included are features on informatics, proteomics and CRISPR.
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New Oxford-GSK Institute aims to unravel complex diseases
GlaxoSmithKline (GSK) and the University of Oxford will collaborate to investigate diseases using technologies such as functional genomics and machine learning.
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Drug intended to treat Alzheimer’s may hold promise for glioblastoma
Verubecestat demonstrated poor results in Alzheimer's trials, but helped suppress tumours in pre-clinical glioblastoma models.
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New target for overeating identified in the brain’s cerebellum
The study uncovered disordered signalling in the brain's cerebellum, offering a novel therapeutic target for Prader Willi syndrome.
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Scientists explore CA2 neuron mitochondria for memory loss targets
The team will receive $2 million over five years to investigate the CA2 brain region for the development of neurological therapies.
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Soluble fibrinogen a potential target for neurodegeneration
In a pre-clinical study, fibrinogen increased the death of mouse brain neurons, suggeting fibrin can have similar toxic effects on neurons.
