news
Plasma membrane protein may generate new neurons in the hippocampus
New research in suggests that the protein Efr3a regulates the BDNF-TrkB signaling pathway, which plays an important role in regulating learning and memory...
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Neurosciences
article
A new approach to Organ-on-a-Chip
Draper's Joe Charest explains how synthetic organoids can lead to safer drug testing, and why organ-on-a-chip technology is the future of drug discovery...
news
Stem cell patch shows early promise in treating heart failure
In a Phase I clinical trial, heart failure patients treated with patches made from their muscle cells showed improved exercise capacity and heart function after one year. Stem cell patch-based therapy may be a viable heart failure therapy and should be validated in larger clinical trials, researchers conclude.
webinar
Assessing neurological ion channel therapeutic and liability targets
10 March 2017 | By Charles River
This webinar explores neurological ion channel therapeutic and liability targets, featuring four subtypes of NMDA receptors. We also discuss the rationale and options for assessment of therapeutic compounds on panels of CNS ion channels for evaluating their risk for CNS liabilities...
news
Human neurons in mouse brains are more susceptible to Alzheimer’s pathology
Cells behave differently when removed from their environments, just as cells that develop in cultures do not behave like cells in living creatures.
news
Brain-machine interfaces: bidirectional communication at last
Since the early seventies, scientists have been developing brain-machine interfaces; the main application being the use of neural prosthesis in paralyzed patients or amputees. A prosthetic limb directly controlled by brain activity can partially recover the lost motor function. This is achieved by decoding neuronal activity recorded with electrodes and…
webinar
Fine Motor Kinematics in In Vivo Pharmacology
1 December 2016 | By Charles River
This webinar details a novel automated and high-precision system to successfully analyze early changes in muscular or neuronal function in disease models...
news
Tweaking immune response key to combat neurodegeneration
19 October 2016 | By Niamh Louise Marriott, Digital Content Producer
A better understanding of how we could manipulate immune system conditions might aid to develop novel therapies against Alzheimer's, Kizil argues...
news
Antibiotics weaken Alzheimer’s disease progression
21 July 2016 | By Niamh Louise Marriott, Digital Content Producer
Antibiotic treatment decreases levels of disease-causing plaques, a hallmark of Alzheimer's disease, according to a new study by neuroscientists...
article
An overview of Alzheimer’s disease drug targets
Alzheimer’s disease (AD) is the most common form of dementia which typically occurs after the age of 65 and is characterised by progressive cognitive impairment...
article
LC3 – Autophagy’s achilles’ heel?
Autophagy is a cellular homeostatic process regulating protein turnover as well as eliciting a stress response to starvation, chemical agents and pathogen infection. It has been implicated in the initiation and progression of several diseases, including neuro-degenerative disorders, Crohn’s disease, infections and cancer...
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Targeting the ubiquitin-proteasome system
The ubiquitin-proteasome system (UPS) is a hierarchical enzymatic cascade that plays an essential role in a broad range of cellular pathways and is found in cytoplasmic and nuclear actions of all eukaryotic cells...
