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AI system develops features of complex brains

15 December 2023 | By Ellen Capon (Drug Target Review)

An AI system could be used to observe how physical constraints shape brains and impact people with cognitive difficulties.

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New lipid nanoparticles effectively deliver RNA to microglia

14 December 2023 | By Drug Target Review

LNPs deliver small interfering RNA to the brain’s microglia to combat inflammation related to Alzheimer’s disease.

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Potential small molecule drug could treat multiple sclerosis

12 December 2023 | By Drug Target Review

The new small molecule targets the glutamate system, reducing MS-like symptoms and repairing damaged myelin in two different animal models.

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Astrocytes gain neural stem cell properties after brain injury

11 December 2023 | By Drug Target Review

Astrocyte plasticity is correlated with upregulation of the Galectin 3 protein, which may greatly contribute to biomarker discovery.

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eBook: A Microscopy Guide For Spatial Biology

11 December 2023 | By Leica Microsystems

In this eBook, discover how to better understand tissue landscapes with different microscopy techniques including multiplex imaging.

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Investigating the genetic changes of the DDX3X gene

8 December 2023 | By Drug Target Review

Using saturation genome editing, researchers have created a map of disease-causing mutations for neurodevelopmental disorders and cancer.

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Documenting the mammalian brain using machine learning

24 November 2023 | By Ellen Capon (Drug Target Review)

Novel approaches to brain disorder diagnosis and treatment may be developed following a project to form a map of the mouse hippocampus.

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Discovering the principles of nervous system function

23 November 2023 | By Ellen Capon (Drug Target Review)

Dr William Schafer, of the MRC Laboratory of Molecular Biology, focuses on the cellular and molecular mechanisms of behaviour, which is one of the fundamental problems of biology. Schafer and his colleagues have studied the nematode Caenorhabditis elegans, using a variety of approaches such as optogenetic neuroimaging and high content…

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Incorporating microglia into brain organoids

16 November 2023 | By Drug Target Review

iPS-cell-derived microglia in brain organoids have enabled scientists to understand early brain development and microglia-associated disease.

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Handbook: Advanced flow cytometry handbook

15 November 2023 | By Sartorius

Don’t miss out on the easier way to do flow cytometry. Learn how to bring speed, throughput, multiplexing and miniaturization, to your bench.

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How a dynein subunit maintains neuronal health

9 November 2023 | By Ellen Capon (Drug Target Review)

Understanding how a molecular transport system inside neurons works could be used for therapeutic approaches to neurodegenerative disease.

Improving Huntington’s disease drug discovery with new reproducible disease models

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Huntington’s disease: danger of repeated DNA sequences

9 November 2023 | By Drug Target Review

Scientists find a way to slow the progression of Huntington’s disease by analysing DNA and find the basis of a potential treatment.

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Utilising CAAR T cells to treat antibody-caused brain disease

6 November 2023 | By Drug Target Review

Researchers have engineered CAAR T cells to destroy harmful antibodies, improving NMDA receptor encephalitis treatment.

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Reduced motor symptoms of Parkinson’s disease

3 November 2023 | By Drug Target Review

In rodent and nonhuman primate animals, circuit-specific gene therapy offers promise for Parkinson’s disease and other brain disorders.

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Metabolic change in hippocampus indicates Alzheimer’s disease

1 November 2023 | By Drug Target Review

Using RNA sequencing, scientists find that metabolic increase in the brain is an early indicator of Alzheimer's disease.

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Neurosciences