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A new mechanism of drug resistance discovered for breast cancer
The scientists found the mechanism of drug resistance depends on activation of a protein called KDM1B which controls and regulates gene expression.
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Oncology
Oncology is a branch of medicine that deals with the prevention, diagnosis and treatment of cancer.
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Study uncovers relationship between T cells and CD4
Researchers at the University of Arizona Health Sciences found that CD4 plays an active role in regulating T-cell receptor signalling.
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New gene target for small-cell lung cancer discovered
Deleting the gene POU2AF2 kills cancer cells in deadly subtype of small-cell lung cancer.
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Scientists inhibit cancer cell growth using pyrrolizidine alkaloid
Researchers in Japan have succeeded in inhibiting cancer cell growth using pyrrolizidine alkaloid, a component of plant origin previously thought to be too toxic to administer.
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Cancer immunotherapy drug discovery outsourcing size to increase globally
A report has shown that the immuno-oncology drug discovery outsourcing market is set to be worth $2563 million by 2030.
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T-cell redirecting bispecific antibodies: the next era of immune-based therapies for multiple myeloma?
While the introduction of novel immunotherapies to combat and treat cancer has advanced patient care greatly, ever more effective solutions continue to be required. Here, Dr Edmond Chan, Senior Director, EMEA Therapeutic Area Lead, Haemato-Oncology at Janssen Europe, Middle East & Africa (EMEA), explores how T-cell redirecting bispecific antibodies (TRBAs)…
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Monoclonal antibodies as a strategy to fight cancer
In this exclusive Q&A, Dr Veysel Kayser, Associate Professor at the University of Sydney, Australia, outlines why monoclonal antibodies (mAbs) are such an important tool to combat cancer. He also relates his recent research, as well as the latest trends in the industry.
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Novel method could determine which lymphoma patients will respond to CAR T-cell therapy
A new high-throughput approach has shown how patients whose tumours express CD58 are more likely to respond to CAR T-cell therapy.
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Cellular ‘waste product’ could enhance cancer immunotherapy, study shows
A new study has shown that lactate, a metabolic byproduct produced during exercise, could augment current cancer immunotherapies.
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Findings on pancreatic cancer could improve immunotherapies
Researchers have revealed the immune landscape and microbiome of pancreatic cysts as they progress to pancreatic cancer, providing targets for immunotherapy.
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Researchers find CD39 inhibition could be an effective strategy for immunotherapy
Scientists have discovered adenosine could inhibit CD39, a molecule that suppresses the immune system.
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New method by which T cells can react to lower doses of antigens
Researchers have discovered a way to ignite T cells, potentially increasing the scope and success of T cell-based immunotherapy.
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How T cells migrate from the tissue to the lymph nodes
Scientists have found that unconventional T cells migrate from tissue into the lymph nodes and influence immune responses there.
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A modified TB vaccine could treat bladder cancer
An animal study has shown that a modified vaccine for tuberculosis could treat bladder cancer whilst minimising side effects.
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New research finds cancer-associated fibroblasts can promote or inhibit drug sensitivity
Researchers found that fibroblasts had varying effects on tumour cells based on both the type of non-small cell lung cancer and the drug used for treatment.
