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Targeted cancer vaccines eliminate tumours and prevent recurrence in mice
Researchers have developed an mRNA-based cancer vaccine that is delivered directly into the lymphatic system for a more potent response.
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Oncology
Oncology is a branch of medicine that deals with the prevention, diagnosis and treatment of cancer.
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Scientists have identified novel molecular biomarkers in cells that spread triple-negative breast cancer
The researchers identified key molecular differences between triple-negative breast cancer cells that cling to an initial tumour and those that venture off to form distant tumours.
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A new study has highlighted how an antibody strengthens bonds between cells
The monoclonal antibody 19A11 binds E-cadherin, a protein that helps cells stick together, especially in epithelial layers that line the skin, the gut and other organs.
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Scientists uncover new therapeutic target for treating colorectal tumours
New study has demonstrated that mice deficient in dendritic cell immunoreceptor are resilient against colitis and colonic tumour growth.
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An EGFRvIII-targeted immune-based therapy could potentially treat glioblastoma
A T-cell bispecific antibody shows potent anti-tumour activity in preclinical models of epidermal growth factor receptor variant III (EGFRvIII) mutant glioblastoma.
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Study reveals potential therapeutic targets for pancreatic cancer
Researchers analysed the expression of long non-coding RNAs in samples from patients and tumour cell lines, identifying a group of genes with augmented expression in pancreatic cancer.
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Takeda enters agreement with F-star Therapeutics to license bispecific antibody
F-star Therapeutics has announced a licence agreement with Takeda for a novel next-generation immuno-oncology bispecific antibody.
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Research shows that EBAG9 leads to strengthened immune response to cancer
The scientists say that shutting down the EBAG9 gene allows the body to destroy tumour cells earlier and more radically.
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New discovery in cancer progression paves way to combat the disease
Researchers have identified an important gene that could enable more targeted treatment for cancer.
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Researchers discover new compounds to potentially combat leukaemia
Researchers from the US have identified several new small molecules that can induce mitophagy in leukaemia cells.
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Whole genome sequencing in cancer research
A recent whole genome sequencing study has revealed hidden insights into the causes of cancer. In an exclusive article, Dr Andrea Degasperi from the Early Cancer Institute at the University of Cambridge, UK spoke to Drug Target Review's Ria Kakkad about the study's implications and the future of whole genome sequencing.
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Key protein identified that helps turn pancreatic cancer cells into a more aggressive form
A new study has shown that it is possible to reverse key process that allows pancreatic cancer cells to grow and spread around the body.
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A combination of nanotechnology, chemotherapy and a monoclonal antibody could treat glioblastoma
For the first time, researchers have tested a molecule that combines three distinct technologies against glioblastoma, the most aggressive type of brain cancer.
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Researchers have linked resistance to kidney cancer treatment to low mitochondrial content in cancer cells
When the researchers increased the mitochondrial content with an inhibitor, the cancer cells responded to the treatment.
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Listeria-based booster improves vaccine’s protection against recurring cancer
New research has shown that using viral and bacterial vaccine approaches together is safe and far more effective at fighting the cancer than either approach by itself.
