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New study shows reprogrammed macrophages promote spread of breast cancer
The new findings could help scientists to identify new targets and develop initial concepts to better restrain the metastatic spread of breast cancer.
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Oncology
Oncology is a branch of medicine that deals with the prevention, diagnosis and treatment of cancer.
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Personalised organoid models for rare spinal cancer
Scientists have successfully created viable organoids from tumour samples from five patients with a rare bone cancer called a chordoma, which has few therapeutic options.
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Whole genome sequencing study reveals hidden insights about the causes of cancer
DNA analysis of thousands of tumours has uncovered insights about the causes of cancer, with genetic mutations providing a personal history of the damage and repair processes each patient has been through.
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New screening technique to accelerate the discovery of cancer-fighting drugs
The novel screening technique can identify molecules that can disable dangerous proteins before they cause diseases by blocking them from interacting with a cell’s DNA.
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Novel technique to rapidly find prostate cancer drugs
A new screening assay could be used to identify new drugs to treat resistant forms of prostate cancer.
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Therapeutically effective drugs identified for bladder cancer
By screening various drugs, a new study has found a childhood leukaemia therapeutic is also efficient in treating bladder cancer.
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New combinatorial strategies to treat ovarian cancer
Researchers have found how ovarian cancer tumours defy immunotherapy, identifying new molecular targets that might boost immune response.
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Key takeaways from the AACR Meeting 2022
Drug Target Review's Editor Victoria Rees brings you the highlights from the American Association for Cancer Research Meeting 2022.
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Biodegradable gel boosts immune system’s attack on several cancers in mice
A new biodegradable gel can release drugs and special antibodies that simultaneously deplete macrophages from the surgical site and activate T cells.
webinar
An efficient and effective PIM3 kinase-focused screening cascade for identification of multiple novel and tractable hit series
14 April 2022 | By Eurofins Discovery Services
Watch this free on-demand webinar to understand how to rapidly identify selective, specific, potent and tractable hit series with appropriate ADME characteristics to speed up hit-to-lead.
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Preventing tumour growth
Researchers have developed a novel substance that disables a protein in the cell skeleton, leading to cell death. In this way, substances of this type can prevent the growth of tumours.
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Simple delivery method that enhances a promising cancer treatment
Scientists have developed a delivery method that enhances treatment by adding CAR T cells and specialising signalling proteins to a hydrogel that is injected next to a tumour.
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Innovative therapy that “tricks” and destroys cancer cells
New research has shown iron-like compound holds promise for treating patients with glioblastoma, an aggressive brain cancer.
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How to develop the next generation of CAR T-cell therapies
CAR T cells have shown incredible promise in the clinic, but there is still room for advancement. One avenue for improvement is through modification of the CAR design. However, given the number of exchangeable domains, testing all variations can present a hurdle. In this article, Dr Sarwish Rafiq, Assistant Professor in…
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Mystery behind odd-shaped blood cancer cells revealed
Researchers have found that the Lamin B1 mutation causes odd-shaped nuclei in blood cancer cells, which may lead to improved care for leukaemia patients.