news
Mitochondrial enzyme found to block ferroptosis, presenting cancer target
The mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) can block cell death, new research has shown, making it a cancer drug target.
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Oncology
Oncology is a branch of medicine that deals with the prevention, diagnosis and treatment of cancer.
news
Small molecule screens reveal new class of anticancer compounds
Two screening techniques were used by researchers to find anticancer compounds that target the aryl hydrocarbon receptor.
news
Single-cell map of lung cancer sheds light on tumour development
A spatial atlas of early-stage lung cancer has been compiled at single-cell resolution, revealing new therapeutic targets.
news
Epithelial cells found to communicate in two distinct ways
Epithelial cell communication depends on the side of the cell, which could have implications for understanding how cancer spreads.
news
Stem cell-based vaccine protects mice against pancreatic cancer
Researchers have developed a vaccine using stem cells that protected mice injected with pancreatic cancer cells from developing tumours.
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Team identifies paediatric acute myeloid leukaemia drug target
Researchers have found that the gene mesothelin can be targeted by new antibody-drug conjugates to treat acute myeloid leukaemia in children.
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MIS hormone shown to suppress ovarian follicle development
Researchers have shown how the MIS hormone can prevent ovulation in females, making it a potential new form of contraception.
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New developments in the research field of immuno-oncology
The exciting potential of immunotherapy for cancer treatment continues its exploration and here, Drug Target Review investigates three of the latest pre-clinical developments in immuno-oncology research.
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New 3D organoid model of pancreas developed from human stem cells
Researchers have developed the first 3D organoid models of the pancreas that includes both the acinar and ductal structures.
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Sanguinarine shows promise against triple-negative breast cancer
A new study in cell cultures has shown that the sanguinarine plant compound could be used to treat people with triple-negative breast cancer.
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Study points to treatment approaches for advanced small-cell lung cancer
Having sequenced samples of advanced small-cell lung cancer, researchers have identified patterns linked to resistance to certain therapies.
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Inhibiting METTL3 enzyme combats acute myeloid leukaemia in mice
Scientists have developed a drug called STM2457 which inhibits a key enzyme involved in acute myeloid leukaemia.
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Compound that targets BRAT1 protein could be used to kill cancer cells
Having synthesised the curcusone D compound, researchers demonstrated its promise as the first BRAT1 inhibitor, making it a potential cancer therapy.
news
First patient-derived organoid model for cervical cancer developed
Novel organoid models of cervical cancer and a healthy human cervix have been developed to study the condition and its progression.
webinar
Imaging Mass Cytometry™ of malignant tissue architecture: rare single cells to structured multi-cellular communities
14 April 2021 | By Fluidigm
Watch our free on-demand webinar to learn more about using Imaging Mass Cytometry™ (IMC™) to measure over 40 protein targets with subcellular resolution.
