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Team identifies potential drug to repurpose against melanoma
Researchers say that inhibiting NLRP3 with Dapansutrile could be an effective strategy to prevent melanoma tumour growth.
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Oncology
Oncology is a branch of medicine that deals with the prevention, diagnosis and treatment of cancer.
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Tumour cell vaccine strategy developed for neuroblastoma and melanoma
A combination of checkpoint and small molecule inhibitors showed success at targeting Myc oncogenes in mouse neuroblastoma and melanoma models.
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Glycolytic-pathway inhibition and CTLA-4 blockade to improve immuno-oncology
In this Q&A, Dr Taha Merghoub discusses how a combination of glycolytic-pathway inhibition and immune checkpoint blockade using anti-CTLA-4 in patients with highly glycolytic tumours could present a personalised approach for immuno-oncology.
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Hydrogel used to revert cancer cells back to cancer stem cells
A new hydrogel has been shown to convert cancer cells to cancer stem cells within 24 hours, in six different human cancer cell line types.
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Platelet-based therapeutic formulation targets tumours in mouse models
A new delivery vector using platelets has shown success in pre-clinical trials at delivering photothermal particles and immunostimulators to tumours.
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New drug target identified to potentially fight neuroblastoma
Researchers have revealed that the protein ALYREF promotes the effects of the neuroblastoma gene, MYCN, making it a target.
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Drug Target Review Assays ebook 2021
In this ebook, find articles exploring some of the assays used to identify the most promising COVID-19 drugs and discussing the development of a novel assay to reveal potential peptide therapeutics for cancer.
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Deactivating gene could boost immunotherapy for head and neck cancer
Inhibiting the KDM4A enzyme slowed the growth of head and neck cancer in mouse models, also demonstrating promise to aid immunotherapy.
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Possible method to apply CAR T-cell therapy to solid tumours developed
Researchers have developed a CAR T-cell engineering technique to ensure that only cancer cells are targeted, leaving healthy cells alone in solid tumours.
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New inhibitor found to combat drug-resistant cancer cells
A team has developed a novel inhibitor that blocks a protein in cancer cells, making drug-resistant tumours respond to chemotherapy.
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Analysis of proteomic data reveals potential therapeutic targets for cancer
Researches have provided a proof-of-concept that proteomic analysis could be used to identify drivers of aggressive cancers.
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Engineered stem cells shown to target breast cancer that metastasises to brain
A team have shown that a tumour-suppressing and killing molecule delivered to the brain by stem cells has been successful in mice.
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Researchers use viruses as vectors to deliver cancer vaccines
A team has used two viruses to administer specific tumour components in mice with cancer to stimulate their immune system.
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Blocking Treg pathway sensitises mice to immunotherapy
Researchers have shown that inhibiting Treg activation in tumours can provide effective immune responses without autoimmune toxicity.
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Researchers find MAPK4 enzyme presents target for prostate cancer
Research has shown that MAPK4 activates two molecules in cellular signalling pathways involved in prostate cancer growth.
