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Blimp-1 identified as driver of T-cell activity against cancer
A study has shown that T cells are driven to attack tumours by IL-2 and Blimp-1 in mice, which researchers say could form the basis of cancer therapies.
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Oncology
Oncology is a branch of medicine that deals with the prevention, diagnosis and treatment of cancer.
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Syndecan-4 cell sensory protrusions activate hallmarks of cancer
A study has revealed that activation of syndecan-4 sensory protrusions extending from cells may be a future target for cancer therapy.
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Combination of antibodies could improve cancer immunotherapies
A study has shown that using three antibodies with two different mechanisms of action could be a novel way to improve immuno-oncology treatments.
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Activating c-Cbl gene causes immune system to attack cancer cells
Upregulation of the c-Cbl gene causes degradation of the immune checkpoint protein PD-1 and may provide a possible new avenue for cancer therapies, according to researchers.
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Organoid models for personalised treatments of glioblastomas developed
Lab-grown brain organoids from patients’ glioblastomas could be useful models to rapidly test and identify effective personalised treatments, find researchers.
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Importin-11 identified as new therapeutic target for colorectal cancer
Researchers have discovered that Importin-11, a cell nucleus import protein, is required for colorectal cancer growth and may be a possible target for new therapies.
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Novel mouse model to study melanoma developed
Researchers have created a novel genetically engineered mouse model for the study of melanoma that they say is more efficient than traditional models.
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Exosomes used by researchers as form of novel gene therapy
A study has demonstrated that exosomes can be used as nanocarriers for therapeutic contents, as a new type of gene therapy.
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Extensive tumour protein analysis reveals new therapy targets
New research has categorised hundreds of cancers based on their common protein mutations, highlighting cell components and tumour microenvironments as possible new therapy targets.
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Is a universal vaccine against cancer possible?
A new study has presented a potential strategy for a universal human cancer vaccine. This article delves into the researchers’ findings, exploring their methodologies and results.
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Promising new therapy developed to treat leukaemia
VTP50469, a new targeted therapy for MLL-rearranged leukaemia, shows greater efficacy and fewer side-effects in mice, according to new research.
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Five recent drug target discoveries for pancreatic cancer
This article highlights some of the most recent drug target discoveries that could be used to develop and design a treatment for pancreatic cancer.
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Mouse model for prostate cancer bone metastasis developed
Researchers have developed a cell line that allows the mechanisms of prostate cancer bone metastasis to be studied in immunocompetent mice.
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Root of childhood kidney cancer discovered
The earliest genetic root of Wilms' tumour has been discovered, which could not only lead to improved treatments but to one day being able to screen for cancers like this before tumours develop.
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New generation of CAR T cells developed
Researchers have reprogrammed CAR T cells to prevent them becoming exhausted after prolonged activity, presenting a possible new therapy for solid tumours.
