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Advancing organ-on-a-chip technology
Researchers from the University of Pennsylvania have developed a novel organ-on-a-chip technology called OCTOPUS, an optimised device for growing mini-organs in a dish.
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Organ-on-a-Chip
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A three-dimensional model for rare neuromuscular disorders
Scientists have created a tiny, bioengineered 3D model that mimics the biology of chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy, a pair of rare, devastating neuromuscular diseases.
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Novel way to model conditions that impact the lymph system developed
Researchers at Texas A&M University have applied organ-on-chip models to the lymph system to create the first lymphangion-chip.
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New measures to minimise animal testing to be implemented in Europe
The European Medicines Agency is promoting three principles – replace, reduce and refine – to reduce animal testing in medicine development.
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High-throughput 3D cell migration assays in organ-on-a-chip technologies
Organ-on-a-chip models can provide an alternative to cell cultures, animal models and traditional assays. In this article, Dr Désirée Goubert, Thomas Olivier, Luuk de Haan and Dr Lenie van den Broek explore the advantages of organ-on-a-chip technologies and how they can enable the in vitro study of three-dimensional (3D) cell migration in…
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Airway-on-a-chip technology enables COVID-19 drug repurposing
An airway-on-a-chip has been used to show that amodiaquine inhibits SARS-CoV-2 infection, making it a potential COVID-19 therapeutic.
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New 3D lung-on-a-chip model enables study of respiratory diseases
Scientists have developed a 3D lung-on-a-chip model of the distal lung and alveolar structures, enabling the study of COVID-19.
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Organ-on-a-chip model developed to aid sickle cell disease treatment
Researchers have developed a novel organ-on-a-chip model of sickle cell disease to improve personalised medicine.
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Lung-on-a-chip models enable advanced study of immune response
Researchers have reviewed lung-on-a-chip technologies, finding they are useful for representing the various disease pathologies.
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New liver-on-a-chip model successfully mimics NAFLD
A liver-on-a-chip model has been developed to more fully represent the natural progression of NAFLD than previous models.
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“Organs-on-a-chip” reveal how digestive tract may influence neurological disease
A team has used their new organs-on-a-chip system to replicate the interactions between the brain, liver and colon.
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Organs-on-a-chip model for breast cancer drug cardiac toxicity testing
The newly developed chip includes heart and breast cancer tissues and could be used to predict the cardiac toxicity of chemotherapeutic drugs.
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Current state of NAFLD treatments and the promise of in vitro platforms towards better screening of drug candidates
The heterogeneous pathogenesis of metabolic fatty liver diseases presents researchers with numerous challenges when trying to develop a treatment. This article explores the spectrum of these diseases and presents a novel in vitro platform for screening drug candidates.
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Cornea-on-a-chip could allow for more accurate ophthalmic drug testing
Researchers have developed a device which mimics how blinking and tear movement effect the cornea for use in testing ophthalmic drugs and ocular research.
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Connections between nerves and stem cells may be essential for function
Researchers have demonstrated that stem cells attract neurons with different strengths and that connections between the two may be vital for cancer stem cell function.
