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RNA therapeutics: the key to treat rare disease?
This exclusive interview highlights some of Dr Arthur Suckow’s insights into how his team uses RNA therapies to treat rare diseases such as Charcot-Marie-Tooth 1A.
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Peptide Therapeutics
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Peptides with anticancer potential discovered in new study
Researchers have found peptides that bind to chains of ubiquitin proteins in cancer cells, suggesting they could be used as a therapeutic strategy.
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Novel synthetic peptides could suppress formation of harmful amyloid aggregates
German researchers have designed peptides that bind to amyloidogenic proteins linked to Alzheimer’s and type 2 diabetes, to effectively suppress both cytotoxic amyloid aggregation and amyloid cross-accelerating interactions.
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Implant in mice most effective treatment for pancreatic cancer yet
A new implant that combines internal radiation and chemotherapy dissolved tumours in mice across multiple models.
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Novel approach developed to deliver cancer immunotherapy drug
Researchers have eradicated malignant tumours in mice by combining an immunotherapy agent with a molecular delivery system that targets tumour acidity.
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New antibiotic could stop advance of resistant pathogens
Using computational screening, researchers have discovered an antibiotic called Dynobactin, that halts the advance of antibiotic-resistant bacteria.
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New study highlights how to deliver a protein to the brain quickly
Potential uses for the study could include repairing spinal cord injuries and a range of other localised injection applications.
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Scientists uncover how adult muscle stem cells are regulated
Researchers find that mitochondria’s shape transitions as they elongate and divide are in fact regulating the dormant state of adult muscle stem cells.
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Peptide delivered by nasal spray can reduce seizure activity
A novel peptide augments the brain’s natural mechanism to help prevent seizures and protect neurons in research models of both Alzheimer’s and epilepsy.
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New discovery could lead to treatment for cardiac hypertrophy
Scientists have identified an important new mechanism that causes the heart’s muscle to thicken which markedly increases the risk of irregular heart rhythms and cardiac hypertrophy.
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The power of T-cell immune response to Omicron variants
In a new study, researchers have demonstrated the efficiency of T-cell immune response against the Omicron variant of SARS-CoV-2.
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Enhanced way to generate effective personalised cancer vaccines revealed in study
Scientists have created a pipeline for identifying, prioritising and evaluating potential tumour antigens for personalised cancer vaccines.
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Peptides: a promising alternative to opioids for chronic pain relief
In an exclusive with Drug Target Review, researchers at the University at Buffalo explain how they developed a novel peptide that could be a future treatment for chronic inflammatory pain.
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Product hub: High-throughput screening of cyclic peptide libraries for developing drugs to challenging targets
Professor Christian Heinis explains how peptides could offer the next generation of therapeutics and what is required to screen libraries of cyclic peptides.
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Nanoparticle platform enables enhanced delivery of gene therapies
Scientists have created new nanoparticle-based materials that could be used to deliver gene therapies in an adaptable way.