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Methodology developed to genetically modify lab mice and human cells
A method designed to genetically alter laboratory mice can also be used to produce personalised animal models of an aggressive type of malignant brain cancer in children.
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Personalised Medicine
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The elegant parallel of using CRISPR to understand disease mechanisms
CRISPR is the buzzword of the moment in the drug discovery industry – mainly due to its potential to correct disease-causing mutations. However, those using the technology need to be mindful that it is used responsibly, and possible risks are considered before use. Mark Behlke discusses the potential of CRISPR…
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New model found to improve drug development in pre-clinical trials
Researchers have successfully created a multi-organ in vitro model to test toxicity and efficacy of drugs.
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First blood-brain barrier chip using stem cells developed
Researchers have, for the first time, duplicated a patient's blood-brain barrier (BBB), creating a human BBB chip with stem cells.
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MS treatment potential after condition-causing genes identified
Researchers have found 12 genes which cause MS, creating potential for preventative treatment of the condition.
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EU conditional marketing authorisation announced for ZYNTEGLO
ZYNTEGLO™ is the first gene therapy approved for transfusion-dependent β-thalassemia (TDT).
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A high-throughput approach to developing T-cell immunotherapies
23 May 2019 | By Sartorius
Join us as we discuss the promises and pitfalls associated with developing individualised antigen-specific T-cell therapy products for clinical use.
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Novel findings could improve vaccinations against STIs
Researchers have shown how skin vaccinations could be used as a vaccination strategy for sexually transmitted infections (STIs).
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WINTHER trial yields promising results
Comprehensive tumour profiling promises new therapeutic options for patients with advanced cancer.
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Paving the path towards precision medicine
A method to view the immune cell 'landscape' of bowel cancer tumours could pave the way towards more individualised medicine and treatment...
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Tailoring treatment for acute myeloid leukaemia
Rapid drug response screening for leukaemia stem cells offers clues to relapse and to improving patient-specific therapies...
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T-cells engineered to recognise tumours expressing the CD30 protein marker
Researchers have genetically engineered immune cells to recognise and fight Hodgkin and non-Hodgkin lymphoma cells...
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PSD-95 molecule reveal potential treatment for stroke patients
A novel hybrid approach has revealed a 3D structure of a protein fragment that could serve as a drug target in treating stroke patients...
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Cancer vaccine shows promise for HER2-positive cancers
Treatment with a HER2-targeted therapeutic cancer vaccine provided clinical benefit to several patients with metastatic HER2-positive cancers...
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Nanotherapy offers hope in treating drug-resistant renal cell carcinoma
A research team has developed a nano-platform technology that works in combination with existing chemotherapeutic drugs that may reverse drug-resistance in renal cell carcinoma...
