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Precision Medicine

Blood-brain barrier (BBB) in the human brain - closeup view 3d illustration

news

Blood-brain barrier breakthrough for ALS and Alzheimer’s disease

27 November 2024 | By Drug Target Review

A new blood-brain barrier-crossing platform enables the delivery of therapeutic molecules to the brain, offering potential treatments for ALS and Alzheimer’s disease.

article

The power of big data to advance genomics into clinical care

26 July 2024 | By Drug Target Review, Hylton Kalvaria (Helix)

The integration of genomics into patient care will lead to more precise, personalised treatments. In this Q&A, Hylton Kalvaria, Chief Commercial Officer of Helix, explains how the Helix Research Network is creating a large-scale clinicogenomics dataset to advance research into molecular and genetic determinants of disease risk and drug response.

article

Could illuminating the surfaceome help find new targeted cancer therapies?

11 July 2024 | By Roman Thomas (DISCO Pharmaceuticals)

At the heart of precision oncology is the need to increase our understanding and knowledge of surface proteins found on tumour cells. Here Roman Thomas, CEO of DISCO Pharmaceuticals, explains how it is using cutting-edge technology to explore the surfaceome – a map of the proteins on the cell’s surface…

whitepaper

Beyond the lab: screening

13 June 2024 | By Drug Target Review

This report provides exclusive access to content on innovative screening methods to improve detection and diagnosis of prevalent conditions like cancer and metabolic disease, with expert insights from leading professionals in the field.

article

Vitamin A and its role in psychiatric and other disorders

19 March 2024 | By Dr Murray Cairns (University of Newcastle), Ellen Capon (Drug Target Review)

In this Q&A, Dr Murray Cairns, NHMRC Leadership Research Fellow at the University of Newcastle, shares his insights about the genetic influences on circulating retinol, and explains how a retinol polygenic score could be utilised in a precision medicine approach.

article

Scalable precision design targeting complex product profiles

6 March 2024 | By Dr Víctor Sebastián Pérez (Exscientia), Ellen Capon (Drug Target Review)

We had the privilege of speaking to Dr Víctor Sebastián Pérez, Associate Director of Computational Drug Design, following his presentation at ELRIG UK 2023. He shares his insights into how Exscientia is using AI to design drug candidates for cancer treatment.

Mitochondrial disease Mitochondrial DNA 3D rendering

news

Improved gene editing method for mitochondrial genetic diseases

26 February 2024 | By Drug Target Review

Researchers have developed the world’s first animal model with A-to-G mtDNA edits achieved using engineered TALEDs.

article

A new genetic biomarker to predict immunotherapy success

16 February 2024 | By Ellen Capon (Drug Target Review)

Tumours with a greater IGR burden could respond better to immune checkpoint blockades, advancing precise treatments for patients.

news

The implications of EN-1 overexpression in late-stage PDAC

15 February 2024 | By Drug Target Review

Using tumour organoids, researchers identified that overexpression of Engrailed-1 blocked genes associated with natural cell death.

news

Investigating the inflammatory myocardial microenvironment

13 February 2024 | By Drug Target Review

By studying the molecular cell states within transplanted paediatric hearts, researchers have unlocked new treatment strategies.

article

Using proteomics to overcome glioblastoma resistance

17 January 2024 | By Ellen Capon (Drug Target Review)

Using an AI algorithm to predict glioblastoma’s most active kinase, researchers hope for a next-generation precision therapy targeting resistant cancers.

news

Changes in CD4+ T cells associated with autoimmune diseases

12 January 2024 | By Drug Target Review

Genetic factors that promote disease development accumulated in CD4+ T cells exhibiting specific gene programmes.

article

How AI is accelerating the future of precision medicine

12 January 2024 | By Ellen Capon (Drug Target Review)

Dr Ketan Patel, Clarivate, shares his insights about the use of Real-World Data and genomic biomarker data and discusses how researchers can use these to better detect and diagnose diseases.

news

Potential of precision diagnostics for gestational diabetes mellitus

4 January 2024 | By Drug Target Review

Researchers highlight the need for a more nuanced diagnostic approach, examining whether nonglycemic markers could refine risk stratification.

article

Decoding stem cells for personalised regenerative medicine

2 January 2024 | By Taylor Mixides (Drug Target Review)

Researchers developed a personalised stem cell therapy using a data-driven, single-cell technique based on swift subcellular proteomic imaging.

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Precision Medicine