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Proteogenomics is the systematic and comprehensive integration of proteomics with genomics and transcriptomics. Proteogenomics is opening new hallmarks in biomedical research. Recently, several studies have demonstrated the relevance of proteogenomics in cancer research. This article provides a brief review of the advantages of proteogenomics in precision medicine.
Researchers identify binding site on the amyloid beta peptide that could facilitate better drugs to treat the disease...
Researchers have uncovered a new genetic cause for erythropoietic protoporphyria...
A team of researchers has discovered the role of the protein ZBTB48 in regulating both telomeres and mitochondria, key players involved in cellular ageing.
Investments are now being made to roll out this innovation across healthcare and broaden the scope of the research in this field.
A study has found that abnormal proteins found in Alzheimer's disease, Parkinson's disease, and Huntington's disease all share a ability to cause damage...
The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) is establishing 15 new Research Training Groups to further support early research...
Understanding evolution is one of the cornerstones of biology - evolution is, in fact, the sole explanation for life's diversity on our planet. Based on the evolution of proteins, researchers may explain the emergence of new species and functions through genetic changes or how enzymes with novel functions might be…
A protein that typically helps keep cells organised and on task becomes a tumour suppressor in the face of liver cancer, scientists say.
Changes leading to the hyperactivation of the protein kinase Akt are observed in 50% of all tumours. Understanding Akt’s regulatory mechanisms is therefore essential for developing and improving cancer therapies....
Researchers have uncovered molecular details of how pathogenic bacteria fight back against the human immune response to infection.
Biopharmaceuticals are highly complex protein drugs such as antibodies, cytokines and peptide hormones, which are used for a variety of indication areas, including immunology, neurology, metabolic diseases and cancer. These modern protein drugs may hinder progression of a disease, ease symptoms or assure – in the case of chronic diseases…
The drug discovery landscape is changing: no longer limited to big pharma, it is now within reach of academics and small consortia alike. Regardless of the setting, drug discovery requirements are always the same: strong biological theory, good chemical starting material and high quality protein samples from which to determine…
The success story of Mapp Pharmaceuticals’ experimental drug, ZMapp, during last year’s Ebola outbreak highlights the potential of plant-made monoclonal antibodies (mAbs) as life-saving treatments.
20 March 2015 | By Victoria White
ExpreS2ion Biotechnologies announce the release by its partners at University of Copenhagen of a vaccine against placental malaria for testing in humans...
