news New molecule could complement antibiotics to treat pneumonia 16 November 2021 | By Anna Begley (Drug Target Review) Scientists targeted a mouse's own cells using a synthetic molecule called EEZE, presenting a novel way to treat pneumonia.
news Scientists reveal ultrastructure of Huntington’s disease 15 November 2021 | By Anna Begley (Drug Target Review) Researchers used advanced microscopy and proteomics to unveil new findings on Huntington's disease and open avenues to future treatments.
news Replication proteins a potential new target for COVID-19 vaccines 12 November 2021 | By Anna Begley (Drug Target Review) A new study claims that future COVID-19 vaccines should activate T cells to attack infected cells expressing replication proteins.
news Novel intestine chip enables effective in vitro study of COVID-19 therapies 10 November 2021 | By Anna Begley (Drug Target Review) The intestine chip was infected with a coronavirus to test a variety of drugs, presenting a new method to investigate COVID-19 treatments.
news Soluble fibrinogen a potential target for neurodegeneration 9 November 2021 | By Anna Begley (Drug Target Review) In a pre-clinical study, fibrinogen increased the death of mouse brain neurons, suggeting fibrin can have similar toxic effects on neurons.
news IL-36Ra discovery may help heal skin wounds from ischemia reperfusion 8 November 2021 | By Anna Begley (Drug Target Review) The absence of interleukin-36 receptor antagonist (IL-36Ra) significantly slowed down wound healing in ischemia-reperfusion injuries in mice.
news Researchers identify COVID-19 proteins that cause blood vessel damage 3 November 2021 | By Anna Begley (Drug Target Review) Scientists revealed five proteins that cause blood vessel damage in COVID-19 patients, potentially leading to new drug targets.
news Scientists eliminate key Alzheimer’s feature in animal model 1 November 2021 | By Anna Begley (Drug Target Review) Turning off NHE6 in mice in pre-clinical studies prevented amyloid beta aggregation, a key feature of Alzheimer's disease, pointing to new therapies.
news NMR method could uncover details of cancer and neurodegeneration development 1 November 2021 | By Anna Begley (Drug Target Review) Scientists have used nuclear magnetic resonance (NMR) spectroscopy to investigate the protein p53, which they say could advance cancer studies.
news Experimental mouse model reveals potential progeria treatment strategy 27 October 2021 | By Anna Begley (Drug Target Review) Scientists have found that Hutchinson-Gilford Progeria Syndrome (HGPS) can be prevented with treatments targeting the cardiovascular system using a novel mouse model.
news Novel strategy successfully suppresses HIV infection in mice 25 October 2021 | By Anna Begley (Drug Target Review) A new method, called synapse for T-cell activation (synTac), can attack HIV-infected T cells and may be a new cure for HIV and other diseases.
news Targeting channel in cell lysosome could selectively kill cancer cells 25 October 2021 | By Anna Begley (Drug Target Review) Activating the protein channel TRPML1 induced selective melanoma cell death while sparing normal cells, suggesting a potential pathway for new cancer therapies.
news Novel method refines cryogenic electron microscopy (cyro-EM) 21 October 2021 | By Anna Begley (Drug Target Review) The statistical method known as maximum entropy could improve cryogenic electron microscopy (cryo-EM) for more effective drug treatments.
news Scientists identify protein that prevents HSV-1 brain damage 20 October 2021 | By Anna Begley (Drug Target Review) Mammalian target of rapamycin complex 2 (mTORC2) was found to prevent brain damage in mice infected with herpes simplex virus 1 (HSV-1).
news New vaccination approach could target “core” of all coronaviruses 12 October 2021 | By Anna Begley (Drug Target Review) Researchers have used genetically engineered SARS-CoV-2 Spike proteins to boost antibodies against a range of coronaviruses in mice.
