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Experimental enzyme treatment protects mice from lethal anthrax infection
All mice infected with anthrax spores were completely protected after treatment with a pegylated enzyme known as PEG-CapD-CPS334C.
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HAT proteins could unveil new cancer and Alzheimer’s treatments
The new study used cryo-electron microscopy to visualise the structure of a HAT protein and uncover compounds for drug development.
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“Sleeping” cancer cells could prevent tumour metastasis
A new study prevented the growth of metastatic tumours in mice by forcing cancer cells into a dormant state, pointing to novel treatments.
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Rheumatoid arthritis discovery may lead to novel inflammation blockers
A new study links tumour necrosis factor seen in rheumatoid arthritis with T cell dysfunction, potentially leading to new therapies.
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Antihypertensive drugs could treat cerebral small vessel disease
The antihypertensive drug candesartan cilexetil reduced matrisomal protein accumulation in mice with cerebral small vessel disease.
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Existing cancer drugs could become new Alzheimer’s treatments
An experimental drug for liver cancer and Dasatinib, approved for chronic myeloid leukaemia could be repurposed to treat Alzheimer's disease.
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Nanoscale “computer” a pivotal step for precision medicine
The study paves the way for the construction of complex nanoscale computers for the prevention and treatment of cancer and other diseases.
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New molecule could complement antibiotics to treat pneumonia
Scientists targeted a mouse's own cells using a synthetic molecule called EEZE, presenting a novel way to treat pneumonia.
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Scientists reveal ultrastructure of Huntington’s disease
Researchers used advanced microscopy and proteomics to unveil new findings on Huntington's disease and open avenues to future treatments.
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Replication proteins a potential new target for COVID-19 vaccines
A new study claims that future COVID-19 vaccines should activate T cells to attack infected cells expressing replication proteins.
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Novel intestine chip enables effective in vitro study of COVID-19 therapies
The intestine chip was infected with a coronavirus to test a variety of drugs, presenting a new method to investigate COVID-19 treatments.
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Soluble fibrinogen a potential target for neurodegeneration
In a pre-clinical study, fibrinogen increased the death of mouse brain neurons, suggeting fibrin can have similar toxic effects on neurons.
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IL-36Ra discovery may help heal skin wounds from ischemia reperfusion
The absence of interleukin-36 receptor antagonist (IL-36Ra) significantly slowed down wound healing in ischemia-reperfusion injuries in mice.
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Researchers identify COVID-19 proteins that cause blood vessel damage
Scientists revealed five proteins that cause blood vessel damage in COVID-19 patients, potentially leading to new drug targets.
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Scientists eliminate key Alzheimer’s feature in animal model
Turning off NHE6 in mice in pre-clinical studies prevented amyloid beta aggregation, a key feature of Alzheimer's disease, pointing to new therapies.
