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Inhibiting IRE1α pathway could be novel therapeutic strategy for lupus
A study has revealed that blocking a molecule called IRE1α could prevent the release of neutrophil extracellular traps in lupus pathogenesis.
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Aptamer inhibits SARS-CoV-2 with novel mechanism of action, study shows
An aptamer that can bind a different part of SARS-CoV-2 than known inhibitors could enhance treatments against coronavirus mutations.
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First 3D images of Survival Motor Neuron complex visualised
Researchers have imaged the entire Survival Motor Neuron complex using X-ray diffraction analysis, among other techniques.
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‘Zinc finger’ gene therapy could help to treat Alzheimer’s disease
Promising results have been shown in an animal model of Alzheimer's disease treated with zinc finger protein transcription factors.
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Rhesus macaque model of Alzheimer’s disease developed
Scientists have developed a model of the early stages of Alzheimer's disease in rhesus macaques to better test new treatments.
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Team uses antibodies to tag disease-related proteins for destruction
Researchers have developed a technique utilising antibodies to tag disease-causing proteins, to treat the underlying causes of disease.
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Method for analysing sugar-protein interactions could enable better biologics
A novel machine learning method can explain how glycans stabilise proteins, aiding the discovery and design of protein-based drugs.
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New tool designed to add or remove sugar from proteins shows success
Researchers have developed a new tool that can add or remove sugar from proteins, which could be used to treat currently "undruggable" targets.
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Mosquito protein could hold key to therapeutics against flaviviruses
A study has shown the mosquito protein AEG12 inhibits flaviviruses, the family of viruses that cause yellow fever, dengue and Zika.
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Study shows role IgM antibodies play in preventing thrombosis
A new study has revealed that immunoglobulin-M antibodies recognise microvesicles, which are critical for the progression of thrombosis.
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Analysis of proteomic data reveals potential therapeutic targets for cancer
Researches have provided a proof-of-concept that proteomic analysis could be used to identify drivers of aggressive cancers.
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Researchers identify antibodies with potent effects against malaria
Six antibodies specific to the circumsporozoite protein of the malaria parasite have shown promise as therapeutic interventions, a study has shown.
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SARS-CoV-2 mAb cocktail effective against all known variants of virus
A monoclonal antibody (mAb) cocktail, that targets sites on the Spike protein other than the E484K residue, can neutralise SARS-CoV-2.
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Structure of protein that triggers neurodegeneration isolated and analysed
Using X-ray crystallography and cryo-electron microscopy, researchers have elucidated the structure of the SARM1 protein, a target for neurodegeneration.
video
SARS-CoV-2 vaccines: an interview with Payton Weidenbacher
DTR's Victoria Rees interviews Payton Weidenbacher from Stanford University, who discusses a new potential SARS-CoV-2 vaccine that the team he works on developed using nanotechnology.