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Study provides insight into muscle wasting in cancer patients
Using a mouse model, researchers found that cancer progression led to fewer skeletal muscle ribosomes, likely explaining muscle wasting.
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Deletions in SARS-CoV-2 Spike protein drive antibody escape, study shows
Researchers have found that SARS-CoV-2 evades immune responses by deleting parts of its genetic sequence that encode for the Spike protein.
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Majority retain COVID-19 antibodies for six months after infection
A study has shown that 88 percent of people infected by COVID-19 were able to produce SARS-CoV-2 antibodies after six months.
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Novel protein could neutralise SARS-CoV-2 infection in kidneys
A new protein can trick SARS-CoV-2 and bind to the Spike protein rather than cell membranes in a kidney organoid.
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Targeting the HCF-1 protein causes cancerous cells to self-destruct
Disrupting the interaction between the MYC oncogene and its co-factor, host cell factor (HCF)–1, was sufficient to cause Burkitt’s lymphoma cells to self-destruct in vivo.
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N439K variant of SARS-CoV-2 is resistant to some neutralising antibodies, shows study
The N439K mutation improves the interaction between SARS-CoV-2 Spike protein and the viral receptor ACE2 and eludes antibody-mediated immunity, say investigators.
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Altering balance of fibroblasts could prevent spread of colorectal cancer
Researchers have found that colorectal cancer-associated fibroblasts can be altered using a gremlin 1-neutralising antibody or by overexpressing meflin.
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Biomarkers predict Alzheimer’s five years before onset
The discovery of early plasma biomarkers for Alzheimer's disease could transform outcomes by enabling patients to begin treatment early.
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Heparin inhibits SARS-CoV-2 invasion, finds study
Research suggests heparin could be repurposed for COVID-19 because it can bind to the SARS-CoV-2 Spike protein and prevent the virus from infecting cells in vitro.
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T cells target broad range of SARS-CoV-2 epitopes, study shows
A study has found that T cells combat SARS-CoV-2 by targeting many sites on the coronavirus, not just the Spike protein.
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Novel compound named BC1618 could serve as new diabetes drug
Researchers have identified a new compound that improved responses to insulin and treated diabetes in obese mouse models.
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Researchers develop novel way to identify new cancer drugs
A team has developed a new way to discover peptide therapeutics that inhibit HDAC enzymes and are effective against cancer.
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CAR T cells targeting the CEACAM7 protein show promise in pancreatic cancer
CAR T cells modified to recognise CEACAM7 were able to eliminate pancreatic ductal adenocarcinoma cells in a late-stage model without toxic effects on healthy tissue.
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Rhesus macaques with SARS-CoV-2 develop promising immune response
A study has shown that the immune response of rhesus macaques with SARS-CoV-2 could be reproduced with a vaccine.
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Researchers uncover insights into pioneer transcription factors
A research team has discovered how proteins called pioneer transcription factors turn on vital genes in cells.