news Researchers uncover drivers of memory B cell formation 13 October 2020 | By Hannah Balfour (Drug Target Review) The team demonstrated that expression of Bach2 protein and reduced mTORC1 activity is necessary for germinal B cells to become memory B cells.
news COVID-19 vaccines should not be affected by SARS-CoV-2 mutations, researchers say 12 October 2020 | By Victoria Rees (Drug Target Review) A common SARS-CoV-2 mutation known as D614G should not impact on the efficacy of COVID-19 vaccines, a study has shown.
news Researchers suggest blocking factor D protein could combat SARS-CoV-2 9 October 2020 | By Victoria Rees (Drug Target Review) A team has said that inhibiting the factor D protein could prevent SARS-CoV-2 from turning the immune system against healthy cells.
news SARS-CoV-2 mechanism of infection revealed using cryo-electron microscopy 8 October 2020 | By Victoria Rees (Drug Target Review) Researchers have found that the surface of SARS-CoV-2 can take on at least 10 different structural states when in contact with ACE2.
news New treatment could reverse vision loss caused by retinopathy 6 October 2020 | By Victoria Rees (Drug Target Review) Researchers have developed an experimental compound that could treat vision loss in premature infants and adults.
news Novel tumour spheroids could improve ovarian cancer treatments 5 October 2020 | By Hannah Balfour (Drug Target Review) Researchers have developed a new self-assembling three-dimensional (3D) ovarian cancer tumour model to recreate the in vitro disease more accurately.
news Using CRISPR to develop a cutaneous leishmaniasis vaccine 30 September 2020 | By Hannah Balfour (Drug Target Review) Researchers used CRISPR gene-editing to develop a vaccine able to protect against the spread of the Leishmania major parasite which causes cutaneous leishmaniasis.
news Antibodies from recovered COVID-19 patients inhibit SARS-CoV-2 infection in cells 28 September 2020 | By Victoria Rees (Drug Target Review) Pre-clinical studies in cells and hamsters have shown that potent antibodies from COVID-19 patients can prevent infection from SARS-CoV-2.
news Interactive 3D model of SARS-CoV-2 surface released 25 September 2020 | By Victoria Rees (Drug Target Review) A new interactive map of the surface of SARS-CoV-2, featuring the Spike, Envelope and Membrane proteins, has been released for researchers to use.
news Researchers discover druggable pocket on SARS-CoV-2 Spike protein 22 September 2020 | By Victoria Rees (Drug Target Review) A pocket in the SARS-CoV-2 Spike protein has been discovered by researchers, who say it could be a drug target for COVID-19.
news Novel pseudo-virion probes to study SARS-CoV-2 viral entry 18 September 2020 | By Hannah Balfour (Drug Target Review) The non-infectious quantum dot probes are designed to enable researchers to safely study interactions between the SARS-CoV-2 Spike (S) protein and human cells.
news Mystery glycoprotein could prevent respiratory distress 18 September 2020 | By Hannah Balfour (Drug Target Review) According to researchers, the DMBT1S8 molecule can halt inflammation in the respiratory tract through its interaction with the Siglec-8 receptor on immune cells.
news A novel drug target for viral encephalitis therapies 17 September 2020 | By Hannah Balfour (Drug Target Review) Researchers showed CXCL1 signalling to neutrophils drove brain inflammation in herpes simplex virus (HSV) encephalitis and blocking the protein resulted in less severe disease.
news Drug target to combat three coronavirus diseases identified by researchers 16 September 2020 | By Victoria Rees (Drug Target Review) Researchers studying the PLpro binding site of three coronaviruses, including SARS-CoV-2, say the BL2 loop could be targeted by antiviral drugs.
news Engineered stem cells could evade immune system rejection, study shows 16 September 2020 | By Victoria Rees (Drug Target Review) By editing out a set of proteins on the surface of human pluripotent stem cells, researchers have ensured they will be not be rejected by the body's immune system.
![Ovarian cancer cells forming a cancer spheroid as they grow within the peptide-protein co-assembling material [Credit: Alvaro Mata].](https://www.drugtargetreview.com/wp-content/uploads/ovarian-cancer-spheroid-3D-model-750x500.jpg)
![Ovarian cancer cells forming a cancer spheroid as they grow within the peptide-protein co-assembling material [Credit: Alvaro Mata].](https://www.drugtargetreview.com/wp-content/uploads/ovarian-cancer-spheroid-3D-model-e1601896830935.jpg)
