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To address the receptor dysfunction associated with several neurological diseases, scientists have provided novel insights into a protein-protein interaction that could lead to more effective treatments.
A study has shown that targeting the proteins mtp53 and PARP in triple negative breast cancer could inhibit tumour growth and provide a new treatment option.
A new study has shown that the function of the p38 protein is related to the stimulation of cancer cell division and thus enhances tumour growth.
A study revealed that AKAP8 promotes the alternative splicing of proteins, preventing breast cancer metastasis in animal models and could be the target of future therapies.
Research identified a small molecule that targets the mRNA of α-synuclein and prevents the formation of the protein, an approach which could provide novel neurodegeneration therapies.
Drug Target Review explores the latest applications of stem cells in modelling disease, drug production and the most recent steps in regenerative medicine provided by research.
A key receptor has been examined for the first time at high resolution which could lead to better treatments for conditions such as type 2 diabetes.
A new study is the first to describe a novel pharmacological chaperone that is capable of preventing Alzheimer's disease in mice.
A new method of melting proteins has allowed researchers to identify new potential drug targets by revealing protein-drug interactions.
New findings using CRISPR have shown that the IL-4 and IL-13 proteins can protect the body against inflammation from autoimmune diseases.
Studies have identified that the TPX2 protein recruits the molecular machinery required for the branching microtubule nucleation process, so could be a target for cancer therapies.
A new therapeutic route for combatting treatment-resistant cancer has been identified with the discovery that melanoma cells fight anti-cancer drugs by changing their internal skeleton.
A new study has developed a deep learning approach that analyses protein interactions, which could improve the design of drugs in the future.
Researchers have found inhibiting vascular endothelial growth factor A (VEGFA) signalling can mediate psoriasis development in the epidermis and could be a potential target for novel therapies.
PPP2R2A gene allele deletion in prostate cancers promotes the uncontrolled division of cells, reinstatement of its protein causes cancer cell death, so could provide a new therapeutic option.
