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Protein decoy hinders progress of lung cancer growth in mice
Researchers have slowed the spread of a type of non-small cell lung cancer in mice by neutralising a protein that would otherwise cause tumour growth.
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Potential target found for tuberous sclerosis complex
A study on tuberous sclerosis complex has expanded the knowledge of the formation of this disease and how it can be targeted at the molecular level.
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CNS tumour aggressiveness reduced with new molecule
A microRNA inhibitor has been identified which reduced the sizes of aggressive CNS tumours and improved survival in mice.
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Regeneration mechanism could provide target for liver disease drugs
A newly-discovered molecular mechanism that allows damaged adult liver cells to regenerate could pave the way for drugs for chronic liver diseases.
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RhoA protein function identified in nerve cell development
A recent study has revealed new findings about nerve cell development that could help to facilitate future treatment options for spinal cord injuries.
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Researchers identify novel signalling systems in cells
A study has revealed five new signalling processes in GPCR receptors on cells that have high therapeutic potential.
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New AI software shows the nature of RNA-protein interactions
New software has been developed that can reveal the detailed RNA-binding properties of proteins, which is important for characterising the pathology of many diseases.
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Function of protein involved in liver cancer discovered
The involvement of clathrin in the development of liver cancer has been described for the first time, which could lead to more targeted therapy.
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Clues discovered for why MYH9 gene mutations cause human disorders
A new study has demonstrated for the first time that mutations that affect myosin motor activity result in slower cell movements in vivo.
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Inflammatory protein can protect against the spread of herpes virus
A new study that examined the protein IL-36γ could aid in the development of novel therapeutics to protect against STIs.
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Application note: Assess cell viability and proliferation with colorimetric readouts
MTT and Cell Cytotoxicity assay kits from Abcam can both be used to measure cell proliferation (viable cells) and cytotoxicity. The choice of which assay to use is mainly based on the desired workflow and time required to complete an assay.
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Protective antibody discovery could lead to better flu treatments
Researchers have identified a set of three antibodies that they suggest could become the basis for a new antiviral treatment and inform the development of new influenza vaccines.
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Rhomboid protease role observed using dynamic imaging
Researchers have been able to watch rhomboid proteases in a native lipid environment which may be useful for the development of Parkinson's and malaria medication.
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Microprotein revealed to regulate cell stress by study
Researchers have discovered a microprotein that acts as a regulator of cell stress, which could be used in developing therapies for a wide range of conditions.
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New discovery leads to greater understanding of Alzheimer’s disease
A new study has linked an inflammatory protein to impaired memory mechanisms which could lead towards finding a more effective treatment for Alzheimer's.
