Protein

Genes linked to Alzheimer’s risk have been identified

15 August 2019 | By Nic Losardo (Drug Target Review)

Two genes that influence risk Alzheimer's disease could provide scientists with new targets for delaying the onset of the condition's symptoms.

Single enzyme provides target for new sepsis drugs

14 August 2019 | By Rachael Harper (Drug Target Review)

Researchers have discovered that removing the enzyme, PHLPP1, improves outcomes in a mouse model of sepsis so could be a potential drug target.

Blood-brain barrier role in Alzheimer’s patients revealed by tissue model

13 August 2019 | By Rachael Harper (Drug Target Review)

A new study has found that damage caused by Alzheimer's allows toxins to enter the brain, further harming neurons.

Parkinson’s disease symptoms “improved” by oestrogen

13 August 2019 | By Rachael Harper (Drug Target Review)

New research into sex-based differences of Parkinson's disease could lead to new treatments.

Direct toxic action of beta-amyloid in Alzheimer’s patients identified

12 August 2019 | By Rachael Harper (Drug Target Review)

The cause and trigger of the large clumps of protein beta-amyloid found in the brains of early-stage Alzheimer's patients have been discovered.

Therapeutic target for Kennedy’s disease and prostate cancer proposed

9 August 2019 | By Rachael Harper (Drug Target Review)

A chaperone protein has been identified as a possible therapeutic target for the treatment of Kennedy's disease and prostate cancer.

Potential treatment target identified for Crohn’s disease

9 August 2019 | By Rachael Harper (Drug Target Review)

Researchers have identified a pathway in the immune system activated in Crohn's disease which could lead to investigating new treatments.

Researchers grow genetically engineered mini livers to study disease

6 August 2019 | By Rachael Harper (Drug Target Review)

The first genetically modified mini human livers have been grown in a laboratory, to emulate liver disease progression and test therapeutics.

Experimental treatment slows prion disease

5 August 2019 | By Rachael Harper (Drug Target Review)

A new experiment has not only slowed the progression of the prion disease, scrapie, it also extended the lives of prion-infected mice

Protective protein guards against DNA damage

5 August 2019 | By Rachael Harper (Drug Target Review)

It has been discovered that Polo-like kinase (PLK1) guards against severe DNA damage and could help target fast-growing cancer cells.

Antibody therapy extends survival in mice with pancreatic cancer

1 August 2019 | By Rachael Harper (Drug Target Review)

Scientists have found a way to target and knock out a protein which is widely involved in pancreatic cancer cell growth, survival and invasion.

Cancer cell nutrient pathway mechanism discovered

1 August 2019 | By Victoria Rees (Drug Target Review)

Researchers have discovered the mechanism behind a gateway into cells for glutamine, illuminating potential ways to prevent cancer cells from getting nutrients.

Newly discovered signal could lead to anti-cancer therapies

31 July 2019 | By Drug Target Review

Researchers have newly found that protein CD24 acts as a defensive signal and is used by cancer cells to protect themselves.

New discovery could lead to new treatments for Parkinson’s

30 July 2019 | By Drug Target Review

New discovery makes it possible to design new therapies to replace alpha-synuclein's function in people with Parkinson's disease.

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