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New method could speed up drug development and diminish drug trial fails
A new method of assessing the actions of medicines by matching them to their unique protein receptors could accelerate drug development.
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Protein
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In-depth research maps virulence factor of the influenza A virus in real time
Findings from a recent study could lead to the development of therapeutic approaches against influenza A viruses.
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Tissue-damaging protein channel identified
Researchers have discovered an acid-activated protein which could stop damage to tissues as a result of stroke and other health issues.
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Machine-learning model to analyse protein sequences
A machine-learning model has been developed to analyse protein sequences, giving an insight to their structure, function and phylogeny...
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FGL2 protein may be an effective target for GBM
Researchers have discovered an immune regulator that appears to dictate glioblastoma progression by shutting down immune surveillance...
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Scientists developed a new mouse model of Hirschsprung’s disease
Researchers have developed the first viable mouse model of Hirschsprung’s disease and associated enterocolitis with a defect in GDNF/GFRa1/RET signalling...
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Application note: Rapidly isolate high-producing clones
Find out how to streamline Cell Line Development by identifying high-producing clones with monoclonality assurance in one day.
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Higher radiation tolerance for proteins imaged using LPEM
Liquid-phase electron microscopy could overcome limitations identified through traditional protein imaging techniques and through cro-electron microscopy...
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New frontiers in G protein-coupled receptor drug discovery
G protein-coupled receptors (GPCRs) are seven transmembrane spanning proteins that mediate the physiological responses to a broad array of stimuli, including photons, biogenic amines, peptides and large proteins. They represent the target of approximately one-third of all approved drugs,1 yet paradoxically remain a relatively under-exploited protein class.
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Proteomics: cracking the molecular mystery of diseases and therapeutics
In the wake of the human genome project, molecular biology and genetic technologies are tremendously integrating into biomedical research. Currently, PCR, qPCR, and sequencing are key tools in the clinical laboratory for the detection and characterisation of microorganisms and genetic disorders.
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Oral squamous cell carcinoma prognostic signature identified
Discovery based on analysis of tissue and saliva samples from oral cancer patients shows a correlation between a signature comprising three peptides and the presence of lymph node metastasis...
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Webinar highlights: Cell-based and biochemical high-throughput screening in 1536-well plates
The Small Molecule Screening Facility (SMSF) at the University of Wisconsin Madison is a comprehensive high-throughput screening (HTS) centre where researchers have investigated antibiotic-resistant bacterial infections and screening for protein-protein interactions using HTS methods.
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Frizzled receptors could be drug targets for treating major diseases
Frizzled receptors, from the GPCR family, could soon be a target to treat numerous diseases such as cancer, fibrosis and CVD...
whitepaper
Application note: A complete next-generation sequencing workflow for circulating cell-free DNA isolation and analysis
Circulating cell-free DNA (cfDNA) has been shown to have potential as a noninvasive substrate for the detection and monitoring of tumour cells. As circulating tumour DNA is often present at low frequencies within cfDNA, targeted sequencing is an optimal tool for mutation detection.
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Drug candidate offers hope of vocal improvement for ADNP syndrome
Scientists have uncovered a promising drug candidate that appears to normalise the vocal communication mechanism deficiencies experienced in genetic disorder ADNP.