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NLRP12 protein promotes healthy gut bacteria to curb obesity
Scientists have discovered that the anti-inflammatory protein NLRP12 normally helps protect mice against obesity and insulin resistance when they are fed a high-fat diet...
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Protein
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Fewer side effects from cancer drugs promised
Researchers from Copenhagen have developed a method of accurately using proteins to track the path of a drug through the body to ensure its safety...
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Method developed to facilitate effective protein drugs with fewer side effects
Researchers in Denmark have developed a method that enables better tailored pharmaceuticals with fewer side effects.
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Disrupting genetic processes reverses ageing in human cells
Research has shed new light on genetic processes that may one day lead to the development of therapies that can slow, or even reverse, how our cells age...
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Blocking RNA-silencing protein Ago2 shows promise for obesity prevention
Researchers are hopeful of finding a means to inhibit obesity and its associated health problems after a study in which they blocked an RNA-silencing protein in the livers of mice, preventing obesity and diabetic conditions.
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Expert view: GMP proteins for therapeutic manufacturing: combining consistency, safety, and supply
Cell therapies offer revolutionary new approaches for treating humandisease. Most of these treatments use GMP cytokines and growthfactors for the differentiation, expansion, and maintenance of cells.It is critical that GMP protein suppliers offer the optimal combinationof consistency, safety, and stable supply chain.
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Application Note: Evaluating the specificity and potency of PD-1 and PD-L1 blocking antibodies using AlphaLISA human and mouse PD-1/PD-L1 binding kits
Cancer immunotherapy utilises components of the immune system to treat cancer patients. These therapies are designed to work with a patient’s immune system to increase native anti-tumour responses. One type of immunotherapy relies on antibodies to bind to and inhibit the function of proteins expressed by the cancer cell...
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Expert view: New developments in real‑time live‑cell analysis
Live-cell analysis is now a well-established method that is part of the everyday cell biologist’s armoury for understanding cell biology. For over a decade, the functionality, throughput, and ease of use offered by real-time live-cell analysis has provided a platform for accurate and reproducible cell biology analysis in multiple biomedical…
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Upstream cell culture processes for the production of therapeutic proteins
Drugs of biological origin form the backbone of the drug discovery pipelines for many major pharmaceutical companies. These biologic therapeutics can be defined as proteins derived from eukaryotic cell culture processes. The ability of eukaryotic cells to undertake complex post-translational modifications makes them ideal vehicles for manufacturing proteins emerging from…
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Parkinson’s disease: An endogenous protein might become a candidate for drug development
Researchers have deployed a bacterial import signal in order to deliver Nurr1 into cells...
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The molecular link between ageing and neurodegeneration
Researchers have described the discovery of a molecular link between ageing and a major genetic cause of both ALS and FTD...
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NanoMIPs efficiently target and eliminate cancer cells
A joint research team has demonstrated the possibility of developing a new type of anti-neoplastic drugs based on nanoMIPs...
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Modified-RNA vaccine elicits protective response against influenza
A universal flu vaccine that protects people against most influenza strains is one step closer to reality...
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Cocaine relapse is reversed with BDNF microinjections in the brain
Researchers have discovered that a very common protein in the brain has an additional significant role in addiction relapse...