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Protein

news

CLR01 protein found in semen increases the spread of Ebola virus infection

26 June 2018 | By Drug Target Review

Penn study suggests that targeting amyloid fibrils could prevent sexual transmission...

news

Bioactivity profiling supporting the progression of phenotypic hits

22 June 2018 | By Drug Target Review

Addressing the optimisation of hits derived from a target-agnostic phenotypic screen, using a strategy based on combining bioactivity profiling and reference compound characterisation...

news

Researchers uncover new target to stop cancer growth

22 June 2018 | By Drug Target Review

Researchers have discovered that a protein called Munc13-4 helps cancer cells secrete large numbers of exosomes that stimulate tumour progression...

news

Human immune ‘trigger’ map paves way for better treatments

21 June 2018 | By Drug Target Review

A discovery about how human cells are 'triggered' to undergo an inflammatory type of cell death could have implications for treating cancer, stroke and tissue injury, and immune disorders...

whitepaper

Application note: Real-time detection of Gs and Gi Signalling in living cells

20 June 2018 | By BMG Labtech GmbH

Genetically-encoded biosensors from Montana Molecular allow for detection of GPCR signalling...

news

Platypus venom inspires potential new diabetes treatments

18 June 2018 | By Drug Target Review

A metabolic hormone found in the venom and gut of Australia’s iconic platypus will now be investigated for its potential to treat type 2 diabetes...

news

Cancer protein NEDD9 plays a critical role in PAH

14 June 2018 | By Dr Zara Kassam (Drug Target Review)

Study identifies cancer protein as a target for treating fibrosis of the lung arteries with direct implications for patients with pulmonary arterial hypertension...

news

Alpha-synuclein clumps promote Parkinson’s progression

14 June 2018 | By Dr Zara Kassam (Drug Target Review)

Detailed brain cell analysis has helped researchers uncover new mechanisms thought to underlie Parkinson's disease...

news

Eosinophilic esophagitis may be due to missing SPINK7 protein

11 June 2018 | By Drug Target Review

NIH-funded study finds replacement therapy reversed effects in tissue experiments...

news

SMCHD1 protein found essential to X chromosome inactivation

8 June 2018 | By Dr Zara Kassam (Drug Target Review)

The structural protein is required for the chromosome to adopt a conformation that suppresses gene expression...

news

Scientists create ‘genetic atlas’ of proteins in human blood

7 June 2018 | By Drug Target Review

Researchers have created the first detailed genetic map of human proteins...

Eleen Shum, Manager, R&D Genomics Applications - BD

article

Expert view: Discovering neuronal cell types

4 June 2018 | By Eleen Shum (Manager - R&D Genomics Applications - BD)

Target the genes that matter for efficient sequencing and analysis with custom-targeted gene panels.

article

Supporting the progression of phenotypic hits with bioactivity profiling

4 June 2018 | By Drug Target Review

Bioactivity profiling has been traditionally used to assess the selectivity of new drug candidates in the context of target-based approaches, where pharmacological selectivity is a key requirement.

news

CRISPR approach could limit toxicity of CAR-T therapy in AML

4 June 2018 | By Dr Zara Kassam (Drug Target Review)

New study uses CRISPR/Cas9 to make CD33 CAR T cells cancer-specific...

news

Researchers use blood serum markers to develop lupus risk index

1 June 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers have developed an index that identifies the risk for lupus based on the presence and amount of IgG and IgM antibodies and levels of C1q...

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Protein