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Application note: Performing NanoBRET with the Varioskan LUX multimode reader
In this paper, Thermo Fisher Scientific aim to assess the performance of Thermo Scientific Varioskan LUX when running NanoBRET.
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Using bioinformatics sequence similarities to optimise repurposing activities
A significant amount of selectivity and potency data originating from screening of drug targets is generated each year and deposited in public databases. This can be exploited to accelerate drug discovery, in particular, for a variety of repurposing activities...
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Q&A: Implementing ADCC assays in QC: when donor variability isn’t an option
DiscoverX recently introduced the single donor-derived KILR CD16 Effector Cells to ensure assay reproducibility for screening, characterisation, and QC lot release of antibody drugs.
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Scientists discover a small molecule that halts kidney disease progression
A team of researchers set out to discover the disease pathways of a rare genetic kidney disease and found a compound that stops the disease in its tracks.
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Healthy mitochondria may prevent Alzheimer’s disease
Scientists have provided a therapeutic approach to slow down the progression of neurodegeneration in Alzheimer's disease...
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FUNDC1 protein in cardiac muscle cells linked to heart failure
Reducing a protein found in the mitochondria of cardiac muscle cells initiates cardiac dysfunction and heart failure...
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New Alzheimer’s animal model more closely mimics human disease
Researchers have found that amyloid-? facilitates the interaction between the plaques and abnormal tau.
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GDF6 gene associated with metastatic melanoma
Researchers have revealed a protein active during early embryo development called GDF6 plays a primary role in metastatic melanoma...
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Protein associated with ALS points to possible targets for therapeutic intervention
Scientists may have found possible targets for therapeutic interventions in the fight against Lou Gehrig’s disease.
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Scientists visualise structure of key DNA repair component
The ATR protein has been imaged at ‘near-atomic resolution’, providing greater insight into its activation in DNA repair.
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Lung tumours communicate with bones to progress disease
Scientists at Massachusetts General Hospital (MGH) have identified how a type of lung cancer co-opts a portion of the immune system via bone marrow to increase tumour progression.
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Scientists make key development in understanding type-2 diabetes mechanism
Scientists at the University of Geneva (UNIGE) have deciphered the mechanisms that link obesity with type-2 diabetes at the cellular level, thus explaining the reasons behind an association that is already well known.
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RT-QuIC testing detects prion protein in the skin of CJD patients
Scientists have detected abnormal prion protein in the skin of patients that have died from Creutzfeldt-Jakob disease...
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AFM-CRISPR technique used to map DNA mutations
Nanomapping technology may transform the way disease-causing genetic mutations are diagnosed and discovered...
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Reducing TIA1 improves nerve cell health in Alzheimer’s disease
Researchers have described a unique model for the biology of Alzheimer's disease which may lead to an entirely novel approach for treating the disease...